Objective: To evaluate if midlife cardiovascular risk factors are associated with risk of late-life
dementia in a large, diverse cohort. Method: The authors conducted a retrospective cohort …

Previous research shows that cardiovascular risk factors in mid-adulthood could increase
the risk of dementia later in life, but studies with very long follow-up are still scarce. We …

Objective: To develop a late-life dementia risk index that can accurately stratify older adults
into those with a low, moderate, or high risk of developing dementia within 6 years. Methods …

Background: Cardiovascular risk factors are associated with a higher risk of developing
dementia. Studies in older populations, however, have often failed to show this relationship …

Background and Objectives The association between vascular risk factors and dementia
varies with age, making generalizability of dementia risk prediction rules to individuals of …

Objective: To examine the association between diabetes in midlife (1963–1968) and
dementia more than three decades later (1999–2001). Methods: The authors characterized …

Based on many experimental and observational studies we now understand that
neurodegenerative brain changes begin by middle age. Characteristics of the risk factors for …

Objective: To determine the association between blood pressure during midlife (40–64
years) to late life (≥ 65 years) and risk of incident dementia. Methods: This study included …

Background and Objectives Cardiovascular risk factors have a recently established
association with cognitive decline and dementia, yet most studies examine this association …

Background: Cellular and animal studies suggest that hypercholesterolemia contributes to
Alzheimer disease (AD). However, the relationship between cholesterol and dementia at the …