[PDF][PDF] The role of FoxP2 in striatal circuitry

JR Van Rhijn - 2019 - pure.mpg.de
Already since the earliest endeavors to study the brain, researchers have been fascinated
by how activity in the brain enables us to interact with the world around us. For example …

[PDF][PDF] The role of FoxP2 in striatal circuitry

J Rhijn - 2019 - repository.ubn.ru.nl
Already since the earliest endeavors to study the brain, researchers have been fascinated
by how activity in the brain enables us to interact with the world around us. For example …

Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons

HY Kuo, SY Chen, RC Huang, H Takahashi, YH Lee… - Brain, 2023 - academic.oup.com
Human speech and language are among the most complex motor and cognitive abilities.
The discovery of a mutation in the transcription factor FOXP2 in KE family members with …

[HTML][HTML] Talking convergence: growing evidence links FOXP2 and retinoic acid in shaping speech-related motor circuitry

M Negwer, D Schubert - Frontiers in neuroscience, 2017 - frontiersin.org
FOXP2 was the first identified monogenic cause of a speech disorder (for review see
Graham et al., 2015). However, it remains to be answered how it affects the development of …

FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder

CSL Lai, D Gerrelli, AP Monaco, SE Fisher, AJ Copp - Brain, 2003 - academic.oup.com
Disruption of FOXP2, a gene encoding a forkhead‐domain transcription factor, causes a
severe developmental disorder of verbal communication, involving profound articulation …

The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders

C Bacon, GA Rappold - Human genetics, 2012 - Springer
Rare disruptions of FOXP2 have been strongly implicated in deficits in language
development. Research over the past decade has suggested a role in the formation of …

Functional characterization of rare FOXP2 variants in neurodevelopmental disorder

SB Estruch, SA Graham, SM Chinnappa… - Journal of …, 2016 - Springer
Background Heterozygous disruption of FOXP2 causes a rare form of speech and language
impairment. Screens of the FOXP2 sequence in individuals with speech/language-related …

Severe speech impairment is a distinguishing feature of FOXP1‐related disorder

RO Braden, DJ Amor, SE Fisher, C Mei… - … Medicine & Child …, 2021 - Wiley Online Library
Aim To delineate the speech and language phenotype of a cohort of individuals with FOXP1‐
related disorder. Method We administered a standardized test battery to examine speech …

Human IPSC derived dopaminergic neurons show reduced activity following heterozygous FOXP2 knockout

JR Van Rhijn, Y Shi, NN Kasri, D Schubert - frontiersin.org
Motivation Heterozygous mutations of the transcription factor FOXP2 in humans lead to
childhood apraxia of speech. FOXP2 is highly expressed in GABAergic and dopaminergic …

[PDF][PDF] Reduced excitatory activity in a human dopaminergic model for FOXP2 homozygous deletion

JR van Rhijn, Y Shi, M Frega, D Schubert, T Maricic… - FOXP2 IN, 2019 - pure.mpg.de
Heterozygous mutations of the transcription factor FOXP2 in humans lead to childhood
apraxia of speech (CAS). FOXP2 is highly expressed in GABAergic and dopaminergic …