[HTML][HTML] Single cell Raman spectroscopy to identify different stages of proliferating human hepatocytes for cell therapy

C Ma, L Zhang, T He, H Cao, X Ren, C Ma… - Stem Cell Research & …, 2021 - Springer
Background Cell therapy provides hope for treatment of advanced liver failure. Proliferating
human hepatocytes (ProliHHs) were derived from primary human hepatocytes (PHH) and as …

[HTML][HTML] Applying machine learning for multi-individual Raman spectroscopic data to identify different stages of proliferating human hepatocytes

B Shen, C Ma, L Tang, Z Wu, Z Peng, G Pan, H Li - Iscience, 2024 - cell.com
Cell therapy using proliferating human hepatocytes (ProliHHs) is an effective treatment
approach for advanced liver diseases. However, rapid and accurate identification of high …

Raman spectroscopic investigation of the human liver stem cell line HepaRG

O Ryabchykov, K Bräutigam, K Galler… - Journal of Raman …, 2018 - Wiley Online Library
In this work, Raman spectroscopic cell imaging approaches and a discrimination between
HepG2, nondifferentiated hepatic stem cell line HepaRG, and differentiated hepatocyte‐like …

[HTML][HTML] Detection of hepatic maturation by Raman spectroscopy in mesenchymal stromal cells undergoing hepatic differentiation

HH Wu, JH Ho, OK Lee - Stem Cell Research & Therapy, 2016 - Springer
Abstract Introduction Mesenchymal stromal cells (MSCs) are well known for their application
potential in tissue engineering. We previously reported that MSCs are able to differentiate …

Label-free evaluation of maturation and hepatotoxicity of human iPSC-derived hepatocytes using hyperspectral Raman imaging

M Li, Y Ueyama-Toba, M Lindley, G Kongklad… - Analytical …, 2023 - ACS Publications
To promote the clinical application of human induced pluripotent stem cell (hiPSC)-derived
hepatocytes, a method capable of monitoring regenerative processes and assessing …

[HTML][HTML] Assessment of Primary Human Liver Cancer Cells by Artificial Intelligence-Assisted Raman Spectroscopy

C Esposito, M Janneh, S Spaziani, V Calcagno… - Cells, 2023 - mdpi.com
We investigated the possibility of using Raman spectroscopy assisted by artificial
intelligence methods to identify liver cancer cells and distinguish them from their Non-Tumor …

Discrimination and classification of liver cancer cells and proliferation states by Raman spectroscopic imaging

T Tolstik, C Marquardt, C Matthäus, N Bergner… - Analyst, 2014 - pubs.rsc.org
Discrimination of nodular lesions in cirrhotic liver is a challenge in the histopathologic
diagnostics. For this reason, there is an urgent need for new detection methods to improve …

Laser tweezer Raman spectroscopy combined with deep neural networks for identification of liver cancer cells

W Shuyun, F Lin, C Pan, Q Zhang, H Tao, M Fan, L Xu… - Talanta, 2023 - Elsevier
Rapid identification of cancer cells is crucial for clinical treatment guidance. Laser tweezer
Raman spectroscopy (LTRS) that provides biochemical characteristics of cells can be used …

Exploitation of the hepatic stellate cell Raman signature for their detection in native tissue samples

K Galler, F Schleser, E Fröhlich, RP Requardt… - Integrative …, 2014 - academic.oup.com
Hepatic stellate cells (HSCs) surround liver sinusoids and store retinol while they are
quiescent. During fibrotic liver diseases and acute-on-chronic liver failure they change to the …

Raman-based identification of circulating tumor cells for cancer diagnosis

C Krafft, C Beleites, IW Schie… - … 2016: Advances in …, 2016 - spiedigitallibrary.org
Circulating tumor cells (CTCs) that can be extracted from body fluids offer new prospects in
cancer diagnostics. An overview about our recent achievements is presented to use Raman …