Studies performed in humans and animal models have implicated the environment in the
etiology of type 1 diabetes (T1D), but the nature and timing of the interactions triggering β …

The role of viral infection in the pathogenesis of type 1 diabetes in humans remains an open
question. Viruses are variously thought to be causative, preventive, or irrelevant. The rat …

During the last decades, the incidence of type 1 diabetes (T1D) has increased significantly,
reaching percentages of 3% annually worldwide. This increase suggests that besides …

Kilham rat virus (KRV) infection of BB/Wor diabetes-resistant (DR) RT1u rats induces
autoimmune diabetes without direct cytolytic infection of pancreatic β-cells and is a new …

Epidemiological and experimental data strongly suggest that type 1 diabetes occurs as a
detrimental combination of genetic predisposition and environmental triggering factors …

The BB rat is an important rodent model of human type 1 diabetes (T1D) and has been used
to study mechanisms of diabetes pathogenesis as well as to investigate potential …

OBJECTIVE The contribution of antecedent viral infection to the development of type 1
diabetes in humans is controversial. Using a newer rat model of the disease, we sought to 1) …

Autoimmune diabetes mellitus affects> 50% of diabetes-prone BB (DP BB) rats but< 1% of
diabetes-resistant BB (DR BB) rats. We report an outbreak of spontaneous diabetes among …

More than 10 viruses have been reported to be associated with the development of type 1
diabetes‐like symptoms in animals, with the best evidence coming from studies on the D …

Diabetes mellitus is a metabolic process that leads to hyperglycemia. It causes diabetes low
levels of the diabetic hormone insulin, damage to beta cells in the pancreatic islets leads to …