Diabetes mellitus (DM) and its complications are now increasing in human and animals.
There are two major types of DM; insulin dependent diabetes mellitus (lDDM) and non …

In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8+ T
cells, together with a significant number of other inflammatory cells, including CD8+ T …

Syndromes resembling human diabetes occur spontaneously in some animal species.
Alternatively, they can also be induced by treating animals with drugs or viruses, excising …

The braking of tolerance or unresponsiveness to self-antigens, involving the activation of
autoreactive lymphocytes, is a critical event leading to autoimmune diseases. The precise …

Type I diabetes mellitus is an autoimmune disease resulting from the interaction of genetic
and environmental factors. A virus that was identified serologically as Kilham's rat virus …

Group B coxsackieviruses (CVB) are believed to trigger some cases of human type 1
diabetes (T1D), although the mechanism by which this may occur has not been shown. We …

This chapter highlights the many homologies with the human disease and some of the
unique features of the BioBreeding (BB) rat. The BB rat is one of two unique rodent models …

Male CD-l mice were challenged with a diabetogenic strain (E2) of coxsackievirus B4
(CVB4). At 7 weeks, 6 months, and 1 year after inoculation, mean histopathologic scores …

Kilham rat virus (KRV) causes autoimmune diabetes in diabetes-resistant BioBreeding (DR-
BB) rats; however, the mechanism by which KRV induces autoimmune diabetes without the …

The non-obese diabetic (NOD) mouse spontaneously develops type 1 diabetes (T1D) and
has thus served as a model for understanding the genetic and immunological basis, and …