Mitochondrial DNA (mtDNA) faces the universal challenges of genome maintenance: the
accurate replication, transmission and preservation of its integrity throughout the life of the …

The accurate maintenance of mitochondrial DNA (mtDNA) is required in order for eukaryotic
cells to assemble a functional electron transport chain. This independently-maintained …

Mitochondria have their own genome, which is essential for proper oxidative
phosphorylation and hence for a large part of ATP production in a cell. Although …

For many years, the repair of most damage in mitochondrial DNA (mtDNA) was thought
limited to short‐patch base excision repair (SP‐BER), which replaces a single nucleotide by …

Mitochondrial DNA (mtDNA) alterations are implicated in a broad range of human diseases
and alterations of the mitochondrial genome are assumed to be a result of its high …

DNA molecules in mitochondria, just like those in the nucleus of eukaryotic cells, are
constantly damaged by noxious agents. Eukaryotic cells have developed efficient …

Human mitochondria harbor an essential, high copy number, 16,569 base pair, circular DNA
genome that encodes 13 gene products required for electron transport and oxidative …

Mitochondria play a crucial role in a variety of cellular processes ranging from energy
metabolism, generation of reactive oxygen species (ROS), and Ca 2+ handling to stress …

Mitochondria are double membrane organelles in eukaryotic cells that provide energy by
generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are …

As the primary cellular location for respiration and energy production, mitochondria serve in
a critical capacity to the cell. Yet, by virtue of this very function of respiration, mitochondria …