No detrimental effect of a positive family history on long-term outcomes following radical prostatectomy

JMS Brath, S Grill, DP Ankerst, IM Thompson Jr… - Journal of …, 2016 - journals.lww.com
Purpose Overall 1 in 5 patients with prostate cancer has a positive family history. In this
report we evaluated the association between family history and long-term outcomes …

Familial prostate cancer research: meaningfulness of hereditary criteria in view of demographic change

K Herkommer, M Heimpel, JE Gschwend - Der Urologe, 2014 - Springer
Background In view of demographic changes and previous research results, it is debatable
whether hereditary criteria should be further applied when it comes to determining the status …

A systematic review and meta‐analysis of familial prostate cancer risk

LE Johns, RS Houlston - BJU international, 2003 - Wiley Online Library
OBJECTIVE To identify published studies quantifying familial prostate cancer risks in
relatives of prostate cancer cases and, by meta‐analysis, obtain more precise estimates of …

Insights into Chinese prostate cancer germline gene mutation profile: HOXB13 G84E mutation is unsuitable for genetic testing.

B Dong, B Yang, Y Li, W Chen, J Li, Z Xu, K Wu… - 2020 - ascopubs.org
e17515 Background: Philadelphia Prostate Cancer Consensus Conference 2017
developed an expert consensus-driven working framework for comprehensive genetic …

Familial prostate cancer from the family-cancer database

K Hemminki, C Dong - European Journal of Cancer, 2000 - Elsevier
The aim of this study was to calculate the familial risk for prostate cancer (PC) for different
family relationships. PC was studied in the Swedish Family-Cancer Database, updated in …

2286 FREQUENCIES OF PROSTATE CANCER RISK VARIANTS IN EARLY ONSET AND FAMILIAL PROSTATE CANCER

BT Helfand, BB McGuire, KA Delli-Zotti… - The Journal of …, 2011 - auajournals.org
METHODS From a radical prostatectomy series, 1256 Caucasian men were genotyped for
17 different risk alleles on chromosomes 2, 3, 5, 8, 10, 11, 17, 19 and X. We compared the …

Incidence of cancer in finnish families with clinically aggressive and nonaggressive prostate cancer

S Pakkanen, E Pukkala, H Kainulainen… - … , biomarkers & prevention, 2009 - AACR
Background: Clinical features of familial prostate cancer (PCa) and other malignancies
associated with PCa are poorly described. Using a large family-based data registry of …

Prostate cancer incidence and survival in relation to prostate cancer as second cancer in relatives

G Zheng, J Sundquist, K Sundquist, J Ji - Cancer Medicine, 2022 - Wiley Online Library
Objectives To investigate if the risk of prostate cancer (PC) differs based on the order of
primary PC diagnosed in first‐degree relatives (FDRs) given possibly different risk factors for …

Inherited risk assessment of prostate cancer: it takes three to do it right

J Xu, CV Labbate, WB Isaacs, BT Helfand - Prostate Cancer and …, 2020 - nature.com
Inherited risk for prostate cancer (PCa) is well established with estimated heritability at
57%[1]. Currently, all professional guidelines for PCa screening recommend family history …

Genetic profiling in the diagnosis of hereditary prostate cancer: Where do we stand?

K Boehm, C Thomas, I Tsaur - Aktuelle Urologie, 2018 - europepmc.org
Prostate cancer has a heterogeneous genetic profile compared with other tumour entities.
Accordingly, there are also various mutations that increase the risk of prostate cancer. Some …