Prostate cancer has a heterogeneous genetic profile compared with other tumour entities.
Accordingly, there are also various mutations that increase the risk of prostate cancer. Some …

Background In a large number of studies a positive family history is documented as one of
the main risk factors for the development of prostate cancer. In a US population an …

Background: Familial prostate cancer risk estimates are inflated by clinically insignificant low-
risk cancer, diagnosed after prostate-specific antigen testing. We provide age-specific …

Purpose To assess whether a first-degree family history or a fatal family history of prostate
cancer (PCa) are associated with postoperative upgrading and upstaging among men with …

Recent advances in our understanding of genetic factors that contribute to prostate cancer
(PCa) susceptibility have the potential to improve disease screening, diagnosis, and …

METHODS 18 institutions provided clinical and genotype data on up to 36 different PC risk
SNPs. We evaluated more than 25,000 men with PC (including 7,873 men with low-, 8303 …

272 Background: Family history (FH) is a well-documented risk factor for prostate cancer
(PCa). Certain cancers (Ca) are also shown to co-segregate in families. This study …

Purpose: Prostate cancer is typically a disease of elderly men and, therefore, it has not been
well characterized in those affected at a young age. With the advent of serum prostate …

Prostate cancer (PCa) is the most common cancer among men with a lifetime risk of 12%
and median age of diagnosis of 66. 1 In 2020, 191,930 new cases are expected to be …

BACKGROUND To identify associations of other cancers with hereditary prostate cancer
(HPC) we estimated relative risks (RRs) of 36 different cancers in relatives of prostate cancer …