Klotho, an important anti-aging protein, may be related to elevated blood pressure (BP) and
arterial stiffness. We aimed to investigate associations between the serum klotho …

Background Low levels of the Klotho protein are associated with accelerated tissue aging,
including arterial stiffness, in patients with cardiovascular and renal diseases. However, this …

The Klotho gene, identified as an 'aging suppressor'gene, encodes a single-pass
transmembrane protein. The extracellular domain of Klotho is cleaved and released in the …

Background and aims Evidence indicates that serum Klotho concentration is associated with
mortality in patients with chronic kidney disease (CKD). However, evidence on this …

The Klotho gene is a suppressor of the aging phenomena, and the secretion as well as the
circulation of Klotho proteins decrease with aging. Although habitual exercise has antiaging …

Background Klotho was originally identified in a mutant mouse strain unable to express the
gene that consequently showed shortened life spans. In humans, low serum Klotho levels …

Background Klotho, a protein linked to aging, has emerged as a pivotal player in mineral
bone metabolism and might explain the relationship between chronic kidney disease (CKD) …

Results The median klotho concentration was 630 pg/ml (478–816, 25th to 75th percentile).
Within the cohort, 2093 (76%) of 2774 participants had prevalent hypertension and 476 …

Background/Aims: Serum soluble Klotho (sKlotho) plays a role in cardiovascular disease in
some populations. However, information regarding the effect of serum sKlotho on …

Background It has been shown that Klotho protects vascular endothelial function. Given that
a single bout of resistance‐exercise‐induced hypertensive stimulus causes endothelial …