The inability to discriminate between threat and safety is a hallmark of stress-induced
psychiatric disorders, including post-traumatic stress disorder. Dorsolateral bed nucleus of …

Oxytocin (OT) is a hypothalamic neuropeptide that modulates fear and anxiety-like
behaviors. Dorsolateral bed nucleus of the stria terminalis (BNST dl) plays a critical role in …

Anxiety and trauma-related disorders are characterized by significant alterations in threat
detection, resulting in inadequate fear responses evoked by weak threats or safety stimuli …

Despite its relatively well-understood role as a reproductive and pro-social peptide, oxytocin
(OT) tells a more convoluted story in terms of its modulation of fear and anxiety. This …

Excessive fear learning and generalized, extinction-resistant fear memories are core
symptoms of anxiety and trauma-related disorders. Despite significant evidence from clinical …

Fear and anxiety can be described as emotional and physical responses to predictable and
unpredictable threats. While the amygdala is necessary for context and cued fear …

The bed nucleus of the stria terminalis (BNST) has been implicated in conditioned fear and
anxiety, but the specific factors that engage the BNST in defensive behaviors are unclear …

Background The ability to differentiate stimuli that predict fear is critical for survival; however,
the underlying molecular and circuit mechanisms remain poorly understood. Methods We …

Recent work indicates that the bed nucleus of the stria terminalis (BNST) is critically involved
in the regulation of conditioned fear responses to unpredictable threats. Here we examined …

While results from many past studies have implicated the bed nucleus of the stria terminalis
(BNST) in mediating the expression of sustained negative affect, recent studies have …