Mechanism and potential treatment of the “no reflow” phenomenon after acute myocardial infarction: role of pericytes and GPR39

C Methner, Z Cao, A Mishra… - American Journal of …, 2021 - journals.physiology.org
The “no reflow” phenomenon, where the coronary artery is patent after treatment of acute
myocardial infarction (AMI) but tissue perfusion is not restored, is associated with worse …

Mechanisms of the “no-reflow” phenomenon after acute myocardial infarction: Potential role of pericytes

S Kaul, C Methner, Z Cao, A Mishra - Basic to Translational Science, 2023 - jacc.org
Pericytes contract during myocardial ischemia resulting in capillary constriction and no
reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size …

A role for pericytes in coronary no-reflow

FM O'farrell, D Attwell - Nature reviews cardiology, 2014 - nature.com
Despite efforts to restore tissue perfusion after myocardial infarction, coronary no-reflow—a
failure to achieve adequate reperfusion of the cardiac microcirculation—is a common …

Pericytes constrict blood vessels after myocardial ischemia

MA Costa, AE Paiva, JP Andreotti, MV Cardoso… - Journal of molecular and …, 2018 - Elsevier
No-reflow phenomenon is defined as the reduced blood flow after myocardial ischemia. If
prolonged it leads to profound damages in the myocardium. The lack of a detailed …

No-reflow phenomenon: maintaining vascular integrity

RA Kloner - Journal of cardiovascular pharmacology and …, 2011 - journals.sagepub.com
The no-reflow phenomenon relates to the inability to reperfuse regions of the myocardium
after ischemia, despite removal of the large epicardial coronary artery occlusion. The …

Effect of elevated reperfusion pressure on “no reflow” area and infarct size in a porcine model of ischemia–reperfusion

C Pantsios, C Kapelios, S Vakrou… - Journal of …, 2016 - journals.sagepub.com
Background: The “no reflow” phenomenon (microvascular obstruction despite restoration of
epicardial blood flow) develops postreperfusion in acute myocardial infarction and is …

Modulation of individual susceptibility to the no-reflow phenomenon after acute myocardial infarction

K Iwakura - Current pharmaceutical design, 2013 - ingentaconnect.com
Coronary reperfusion using primary percutaneous coronary intervention (PCI) dramatically
reduces morbidity and mortality among patients with acute myocardial infarction (AMI) …

Coronary microcirculation and the no-reflow phenomenon

E Oikonomou, K Mourouzis, G Vogiatzi… - Current …, 2018 - ingentaconnect.com
The no-reflow phenomenon refers to the post-percutaneous coronary intervention condition
in which, despite re-establishing epicardial coronary vessel patency, the flow to the …

No-reflow phenomenon. A new target for therapy of acute myocardial infarction independent of myocardial infarct size

RA Kloner, W Dai, SL Hale - Journal of Cardiovascular …, 2018 - journals.sagepub.com
The no-reflow phenomenon is a failure to reperfuse portions of previously ischemic tissue
when patency of the large arteries perfusing an organ has been reestablished. This …

No-reflow: a heterogeneous clinical phenomenon with multiple therapeutic strategies

L Galiuto, F Crea - Current pharmaceutical design, 2006 - ingentaconnect.com
Previously defined as a shotcoming to achieve uniform intramyocardial reperfusion after
prolonged but reversible coronary occlusion, only recently has no-reflow phenomenon been …