This study aims to explore and characterize the role of pediatric sedation via rectal route. A
pediatric physiologically based pharmacokinetic-pharmacodynamic (PBPK/PD) model of …

Objective We aimed to 1) develop physiologically based pharmacokinetic/
pharmacodynamic (PBPK/PD) models of a novel midazolam rectal gel in healthy adults, 2) …

Abstract Background and Objectives Midazolam rectal gel is a novel rectal formulation that
may be a promising and potential alternative to oral administration for pediatric sedation …

Midazolam (MDZ) is used for sedation in surgical procedures; its clinical effect is related to
its receptor affinity and the dose administered. Therefore, a pharmacokinetic …

Children are not small adults because besides size there are subtle physiological and
biochemical differences between children and adults. Like adults, children also require …

Background: Physiological‐based pharmacokinetic models have been used to describe
midazolam clearance (CL) maturation. There are no maturation descriptors of CL from …

Introduction In the absence of a licensed formulation in many countries worldwide,
ADV6209, an innovative 2 mg/ml oral solution of midazolam containing cyclodextrin, has …

The aim of this study was to demonstrate the value of mechanistic simulations in gaining
insight into the behaviors of modified release (MR) formulations in vivo and to use the …

Midazolam is one of many bitter drugs where provision of a suitable oral paediatric
formulation, particularly in the pre‐anaesthetic setting, remains a challenge. To overcome …

Background Midazolam is a first-line drug for the treatment of status epilepticus, both by
buccal and intravenous administration. In children and adolescents with obesity, midazolam …