Background Midazolam is used widely as a sedative to facilitate mechanical ventilation. This
prospective study investigated the population pharmacokinetics of midazolam in very …

disaster before any sign of trouble was detected. Page 1 536 no cyanosis, change in breath
sounds, or hemodynamic instability. If the pulse oximeter had not been in use, the case could …

CYP3A plays an important role in drug metabolism and, thus, can be a considerable liability
for drug-drug interactions. Population pharmacokinetics may be an efficient tool for detecting …

The project SAFEPEDRUG aims to provide guidelines for drug research in children, based
on bottom-up and top-down approaches. Propofol, one of the studied model compounds …

Metoclopramide is commonly used for gastroesophageal reflux. The aims of the present
study were to develop a pediatric population pharmacokinetic (PopPK) model, which was …

Physiologically based pharmacokinetic (PBPK) modeling is an important tool to predict
pharmacokinetic or pharmacodynamic profiles in special populations, especially in children …

Dexmedetomidine is a sedative used in both adults and off‐label in children with
considerable reported pharmacokinetic (PK) interindividual variability affecting drug …

The aim of the current research was to develop an in silico oral absorption model coupled
with an in vitro dissolution/precipitation testing to predict gastric pH-dependent drug-drug …

Aim In view of the increasing prevalence of obesity in adolescents, the aim of this study was
to determine the pharmacokinetics of the CYP3A substrate midazolam and its metabolites in …

Purpose The objective of this study was to assess the bioavailability and the sedative effect
of a single-dose administration of an innovative oral solution of midazolam containing γ …