Prolonged seizures and status epilepticus are a common acute neurological presentation in
pediatric practice. As a result, there is a need for effective and safe medications that can be …

Objectives: To compare the pharmacokinetics and pharmacodynamics of IV midazolam after
cardiac surgery between children with and without Down syndrome. Design: Prospective …

The use of physiologically based pharmacokinetic (PBPK) models in the field of pediatric
drug development has garnered much interest of late due to a recent Food and Drug …

We undertook a prospective study to evaluate the relationship between the onset and
degree of sedation and the midazolam plasma concentration in children between 6 and 18 …

Purpose The objective of this study was to assess the bioavailability and the sedative effect
of a single-dose administration of an innovative oral solution of midazolam containing γ …

The widespread use of drugs for unapproved purposes remains common in children,
primarily attributable to practical, ethical, and financial constraints associated with pediatric …

Purpose: To examine the influence of substituting intranasal (IN) midazolam (MID) for oral
(PO) MID, within the three-drug combination of meperidine (MEP), hydroxyzine (H) and MID …

Pediatric physiologically‐based pharmacokinetic (PBPK) models have broad application in
the drug development process and are being used not only to project doses for clinical trials …

Extending licensed drug use to the pediatric population has become an essential part of the
drug development process. Nonetheless, ethical concerns limit clinical testing in pediatric …

The higher skin surface area to body weight ratio in children and the prematurity of skin in
neonates may lead to higher chemical exposure as compared to adults. The objectives of …