Descending nociceptive modulation from the supraspinal structures plays an important role
in cancer-induced bone pain (CIBP). Rostral ventromedial medulla (RVM) is a critical …

Descending nociceptive modulation from the supraspinal structures has an important role in
cancer-induced bone pain (CIBP). Midbrain ventrolateral periaqueductal gray (vlPAG) is a …

Cancer-induced bone pain (CIBP) is a challenging medical problem that considerably
influences cancer patients' quality of life. Currently, few treatments have been developed to …

Spinal glial reaction and proinflammatory cytokine induction play an important role in the
development of chronic pain states after tissue and nerve injury. The present study …

Bone metastasis of cancer cells leads to severe pain by disrupting bone structure and
inducing central sensitization. Neuroinflammation in the spinal cord plays a decisive role in …

Cancer-induced bone pain (CIBP) treatment remains a clinical challenge because the
pathophysiological mechanisms are not fully understood. Recently, it was verified that …

Bone cancer pain (BCP) seriously deteriorates the life quality of patients, but its underlying
mechanism is still unclear. Spinal microRNAs might contribute to the development of BCP …

Multiple myeloma (MM) is a neoplasia of B plasma cells that often induces bone pain.
However, the mechanisms underlying myeloma-induced bone pain (MIBP) are mostly …

Background Cancer-induced bone pain (CIBP) presents a multiple-mechanism of chronic
pain involving both inflammatory and neuropathic pain, and its pathogenesis is closely …

Spinal disk herniation can induce radicular pain through chemical irritation caused by
proinflammatory and immune responses. Bone marrow mesenchymal stem cells (BMSCs) …