Antihypertensive treatment during pregnancy induces long-term changes in gut microbiota and the behaviors of the attention deficit hyperactivity disorder offspring

HB Li, ML Xu, WJ Xia, YY Dong, B Peng, Q Su… - Toxicology and Applied …, 2024 - Elsevier
The pathogenesis of attention-deficit/hyperactivity disorder (ADHD) has not been fully
elucidated. Gestational hypertension could double the probability of ADHD in the offspring …

Maternal treatment with captopril persistently alters gut-brain communication and attenuates hypertension of male offspring

HB Li, T Yang, EM Richards, CJ Pepine… - Hypertension, 2020 - Am Heart Assoc
Maternal-fetal crosstalk has been implicated in long-term control of the health of offspring,
including transgenerational hypertension. However, current knowledge is limited regarding …

[HTML][HTML] A novel role for maternal stress and microbial transmission in early life programming and neurodevelopment

E Jašarević, AB Rodgers, TL Bale - Neurobiology of stress, 2015 - Elsevier
Perturbations in the prenatal and early life environment can contribute to the development of
offspring stress dysregulation, a pervasive symptom in neuropsychiatric disease …

[HTML][HTML] Maternal pre-pregnancy and prenatal penicillin, neonatal inflammation and growth factors are associated to ADHD in the offspring

S Holmgaard, P Kiilerich, N Borbye-Lorenzen… - Brain, Behavior, & …, 2024 - Elsevier
Abstract Background The etiology for Attention Deficit Hyperactivity Disorder (ADHD) is
generally unknown, but both genetics, biology and environment have been shown to …

Gestational stress and perinatal SSRIs differentially impact the maternal and neonatal microbiome‐gut‐brain axis

JL Pawluski, P Murail, F Grudet, L Bys… - Journal of …, 2023 - Wiley Online Library
Selective serotonin reuptake inhibitors (SSRIs) are the most popular antidepressant
medications used to manage perinatal mood disturbances, yet our understanding of how …

Association between prenatal antimicrobial use and offspring attention deficit hyperactivity disorder

JK Straughen, AR Sitarik, G Wegienka… - Plos one, 2023 - journals.plos.org
Background Gut-brain cross-talk may play an important role in modulating
neurodevelopment. Few studies have examined the association between antimicrobials that …

Prenatal stress disrupts social behavior, cortical neurobiology and commensal microbes in adult male offspring

TL Gur, AV Palkar, T Rajasekera, J Allen… - Behavioural brain …, 2019 - Elsevier
In utero and early neonatal exposure to maternal stress is linked with psychiatric disorders,
and the underlying mechanisms are currently being elucidated. We used a prenatal stressor …

Prenatal stress affects placental cytokines and neurotrophins, commensal microbes, and anxiety-like behavior in adult female offspring

TL Gur, L Shay, AV Palkar, S Fisher, VA Varaljay… - Brain, behavior, and …, 2017 - Elsevier
Recent studies demonstrate that exposure to stress changes the composition of the
intestinal microbiota, which is associated with development of stress-induced changes to …

[HTML][HTML] Pre-and postnatal antibiotic exposure and risk of developing attention deficit hyperactivity disorder–A systematic review and meta-analysis combining …

K Otten, L Keller, AA Puiu, B Herpertz-Dahlmann… - Neuroscience & …, 2022 - Elsevier
This study investigated the effects of early antibiotic exposure on ADHD risk by (1)
integrating meta-analytical evidence from human observational studies examining the …

Perturbation of maternal gut microbiota in mice during a critical perinatal window influences early neurobehavioral outcomes in offspring

C Morel, IM Sanchez, Y Cherifi, N Chartrel… - Neuropharmacology, 2023 - Elsevier
The gut microbiota is increasingly recognized as a key environmental factor that shapes host
development and physiology, including neural circuits formation and function. Concurrently …