Observed Changes in Natural Killer and T cell Phenotypes with Evaluation of Immune Outcome in a Longitudinal Cohort Following Sofosbuvir-Based Therapy for …
TJ Stevenson, Y Barbour, BJ McMahon… - Open forum …, 2019 - academic.oup.com
Background Chronic hepatitis C virus (HCV) infection diminishes immune function through
cell exhaustion and repertoire alteration. Direct acting antiviral (DAA)-based therapy can …
cell exhaustion and repertoire alteration. Direct acting antiviral (DAA)-based therapy can …
Immunological analysis during interferon-free therapy for chronic hepatitis C virus infection reveals modulation of the natural killer cell compartment
M Spaan, G van Oord, K Kreefft, J Hou… - The Journal of …, 2016 - academic.oup.com
Background. Chronic hepatitis C virus (HCV) infection is a global health problem, resulting
in liver failure, hepatocellular carcinoma, and liver-related death. Natural killer (NK) cells are …
in liver failure, hepatocellular carcinoma, and liver-related death. Natural killer (NK) cells are …
Peripheral blood correlates of virologic relapse after Sofosbuvir and Ribavirin treatment of Genotype-1 HCV infection
Background Treatment of chronic hepatitis C virus infection with direct acting antiviral
therapy results in viral elimination in over 90% of cases. The duration of treatment required …
therapy results in viral elimination in over 90% of cases. The duration of treatment required …
Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment
Chronic hepatitis C virus (HCV) infection is characterized by dysregulated natural killer (NK)
cell responses. NKs play a critical role in achieving sustained responses to interferon (IFN) …
cell responses. NKs play a critical role in achieving sustained responses to interferon (IFN) …
[PDF][PDF] Temporal dynamics of inflammatory cytokines/chemokines during sofosbuvir and ribavirin therapy for genotype 2 and 3 hepatitis C infection
AF Carlin, P Aristizabal, Q Song, H Wang… - …, 2015 - Wiley Online Library
The analysis of inflammatory cytokines and chemokines produced during hepatitis C virus
(HCV) infection has advanced our understanding of viral‐host interactions and identified …
(HCV) infection has advanced our understanding of viral‐host interactions and identified …
Characterization of changes in intrahepatic immune cell populations during HCV treatment with sofosbuvir and ribavirin
C Orr, J Aartun, H Masur, S Kottilil… - Journal of viral …, 2019 - Wiley Online Library
Treatment of chronic hepatitis C virus (HCV) infection with direct‐acting antivirals (DAA s)
results in a sustained virologic response (SVR) in most patients. While highly efficacious …
results in a sustained virologic response (SVR) in most patients. While highly efficacious …
Peripheral PD-1+ T Cells Co-expressing Inhibitory Receptors Predict SVR With Ultra Short Duration DAA Therapy in HCV Infection
Direct acting antiviral (DAA) regimens of 12 weeks result in HCV clearance in vast majority
of patients across genotypes. We previously demonstrated an ultra-short regimen of 4 weeks …
of patients across genotypes. We previously demonstrated an ultra-short regimen of 4 weeks …
[HTML][HTML] Successful DAA therapy for chronic hepatitis C reduces HLA-DR on monocytes and circulating immune mediators: A long-term follow-up study
NF Rosário, G do Nascimento Saraiva, T Medeiros… - Immunology …, 2020 - Elsevier
Introduction After DAA treatment for chronic hepatitis C infection, peripheral monocyte
subsets from patients who achieved sustained virological response (SVR) reduced …
subsets from patients who achieved sustained virological response (SVR) reduced …
Sofosbuvir (+) daclatasvir (+) ribavirin in Egyptian patients with hepatitis C virus: Therapeutic outcomes and the prognostic role of natural killer cells
Background One of the prominent causes of chronic liver disease worldwide is the hepatitis
C virus (HCV). HCV believed that innate immunity contributes to a sustained virological …
C virus (HCV). HCV believed that innate immunity contributes to a sustained virological …
[PDF][PDF] Multitarget direct‐acting antiviral therapy Is associated with superior immunologic recovery in patients coinfected with human immunodeficiency virus and …
S Shrivastava, M Bhatta, H Ward… - Hepatology …, 2018 - Wiley Online Library
Patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV)
have higher levels of immune activation, impaired antigen‐specific responses, and …
have higher levels of immune activation, impaired antigen‐specific responses, and …