Helicobacter pylori Neutrophil-Activating Protein Directly Interacts with and Activates Toll-like Receptor 2 to Induce the Secretion of Interleukin-8 from Neutrophils and …

SH Wen, ZW Hong, CC Chen, HW Chang… - International Journal of …, 2021 - mdpi.com
Helicobacter pylori neutrophil-activating protein (HP-NAP)-induced production of reactive
oxygen species (ROS) by neutrophils and monocytes is regulated by pertussis toxin (PTX) …

Helicobacter pylori neutrophil-activating protein induces release of histamine and interleukin-6 through G protein-mediated MAPKs and PI3K/Akt pathways in HMC-1 …

CC Tsai, TY Kuo, ZW Hong, YC Yeh, KS Shih, SY Du… - Virulence, 2015 - Taylor & Francis
Helicobacter pylori neutrophil-activating protein (HP-NAP) activates several innate
leukocytes including neutrophils, monocytes, and mast cells. It has been reported that HP …

The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses

A Amedei, A Cappon, G Codolo… - The Journal of …, 2006 - Am Soc Clin Investig
The Helicobacter pylori neutrophil-activating protein (HP-NAP) is a virulence factor of H.
pylori that stimulates in neutrophils high production of oxygen radicals and adhesion to …

The Role of Helicobacter pylori Neutrophil-Activating Protein in the Pathogenesis of H. pylori and Beyond: From a Virulence Factor to Therapeutic Targets and …

HW Fu, YC Lai - International Journal of Molecular Sciences, 2022 - mdpi.com
Helicobacter pylori neutrophil-activating protein (HP-NAP), a major virulence factor of H.
pylori, plays a role in bacterial protection and host inflammation. HP-NAP activates a variety …

Activation of human neutrophils with Helicobacter pylori and the role of Toll-like receptors 2 and 4 in the response

L Alvarez-Arellano, M Camorlinga-Ponce… - FEMS Immunology & …, 2007 - academic.oup.com
The innate immune response to Helicobacter pylori infection is beginning to be understood
and recent works support a role for Toll-like receptors (TLRs). Our aim was to study the …

The neutrophil-activating protein of Helicobacter pylori (HP-NAP) as an immune modulating agent

MM D'Elios, A Amedei, A Cappon… - FEMS Immunology & …, 2007 - academic.oup.com
During evolution microorganisms have developed several immune modulating strategies.
The Helicobacter pylori neutrophil-activating protein (HP-NAP) is a virulence factor that …

TLR9 and NF-κB Are Partially Involved in Activation of Human Neutrophils by Helicobacter pylori and Its Purified DNA

L Alvarez-Arellano, P Cortés-Reynosa… - PLoS …, 2014 - journals.plos.org
Helicobacter pylori infection represents one of the most common bacterial infections
worldwide. The inflammatory response to this bacterium involves a large influx of neutrophils …

[HTML][HTML] Helicobacter pylori neutrophil-activating protein: from molecular pathogenesis to clinical applications

HW Fu - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Helicobacter pylori (H. pylori) neutrophil-activating protein (HP-NAP) was originally
identified as a virulence factor of H. pylori for its ability to activate neutrophils to generate …

The neutrophil‐activating protein of Helicobacter pylori (HP‐NAP) activates the MAPK pathway in human neutrophils

H Nishioka, I Baesso, G Semenzato… - European journal of …, 2003 - Wiley Online Library
Infection by Helicobacter pylori causes an acute inflammatory response followed by a
chronic infection of the human gastric mucosa characterized by the infiltration of neutrophils …

The contribution of toll-like receptor 2 on Helicobacter pylori activation of the nuclear factor-kappa B signaling pathway in gastric epithelial cells

S Li, M Cao, L Song, P Qi, C Chen, X Wang, N Li… - Microbial …, 2016 - Elsevier
Helicobacter pylori (H. pylori) is a spiral shaped gram-negative bacterium that induces
immune responses in the gastric mucosa. Toll-like receptors (TLRs) play important roles in …