Improving the immunogenicity and protective efficacy of the EtMIC2 protein against Eimeria tenella infection through random mutagenesis

Z Chen, X Wang, N Zhao, L Han, F Wang, H Li, Y Cui… - Vaccine, 2018 - Elsevier
In recent years, directed evolution has emerged as an efficient tool to develop and identify
novel protein variants. Eimeria tenella microneme-2 (EtMIC2) is a promising vaccine …

Pichia pastoris expressed EtMic2 protein as a potential vaccine against chicken coccidiosis

J Zhang, P Chen, H Sun, Q Liu, L Wang, T Wang… - Veterinary …, 2014 - Elsevier
Chicken coccidiosis caused by Eimeria species leads to tremendous economic losses to the
avian industry worldwide. Identification of parasite life cycle specific antigens is a critical step …

Partial protective of chickens against Eimeria tenella challenge with recombinant EtMIC-1 antigen

NS Qi, YY Wang, SQ Liao, CY Wu, MN Lv, J Li… - Parasitology …, 2013 - Springer
Eimeria tenella microneme protein 1 (EtMIC-1) is highly conserved with TgMIC-2, which is
involved in parasite binding specifically to host cells. Little is known about the immune …

[HTML][HTML] Molecular characterization and immune protective efficacy of 3 Eimeria tenella antigens

L Zhang, Z Song, P Li, X Song, X Tang, D Hu - Poultry Science, 2024 - Elsevier
Avian coccidiosis caused by Eimeria is a serious parasitic disease that poses a threat to the
poultry industry. Currently, prevention and treatment mainly rely on the administration of …

Cloning, expression and evaluation of the efficacy of a recombinant Eimeria tenella sporozoite antigen in birds

BM Subramanian, R Sriraman, NH Rao, J Raghul… - Vaccine, 2008 - Elsevier
Eimeria infection in poultry is of significant economic interest worldwide. Development of a
cost-effective sub-unit vaccine that provides cross-protection may help reduce loss in poultry …

In ovo vaccination with the Eimeria tenella EtMIC2 gene induces protective immunity against coccidiosis

X Ding, HS Lillehoj, RA Dalloul, W Min, T Sato… - Vaccine, 2005 - Elsevier
An Eimeria tenella microneme recombinant gene (EtMIC2) and encoded protein were
evaluated as potential vaccines against avian coccidiosis. In ovo inoculation with the EtMIC2 …

Evaluation of immunoprotective effects of recombinant proteins and DNA vaccines derived from Eimeria tenella surface antigen 6 and 15 in vivo

T Geng, L Luo, Y Wang, B Shen, R Fang, M Hu… - Parasitology …, 2022 - Springer
Coccidiosis is an intestinal parasitic disease that causes huge economic losses to the
poultry industry globally. Eimeria tenella belonging to protozoon is the causative agent of …

A potential vaccine candidate towards chicken coccidiosis mediated by recombinant Lactobacillus plantarum with surface displayed EtMIC2 protein

HB Huang, YL Jiang, FY Zhou, CW Shi, WT Yang… - Experimental …, 2020 - Elsevier
Eimeria tenella (E. tenella) has caused severe economic loss in chicken production,
especially after the forbidden use of antibiotics in feed. Considering the drug resistant …

In vivo immunoprotective comparison between recombinant protein and DNA vaccine of Eimeria tenella surface antigen 4

P Zhao, Y Li, Y Zhou, J Zhao, R Fang - Veterinary parasitology, 2020 - Elsevier
Eimeria tenella, belonging to protozoon, is the causative agent of cecal coccidiosis in
chicken and causes enormous impacts for poultry industry. The surface antigens of …

Construction of Eimeria tenella multi-epitope DNA vaccines and their protective efficacies against experimental infection

X Song, L Xu, R Yan, X Huang, X Li - Veterinary immunology and …, 2015 - Elsevier
The search for effective vaccines against chicken coccidiosis remains a challenge because
of the complex organisms with multiple life cycle stages of Eimeria. Combination of T-cell …