Parkinson's disease is a neurodegenerative disorder characterized mainly by damage to the
dopaminergic nigrostriatal system. Recently, the neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6 …

Despite the different animal models of Parkinson's disease developed during the last years,
they still present limitations modelling the slow and progressive process of …

Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting
approximately 1% of the population older than 60 years. Classically, PD is considered to be …

1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) has been used as a potent
neurotoxin to approximate, in animals, the pathology that is observed in human Parkinson's …

This protocol describes our method of producing a reliable mouse model of Parkinson's
disease (PD) using the neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) …

Fourteen male Göttingen minipigs were used in this study. Nine were administered N-methyl-
4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) at a dosage of 1 mg/kg/day, SC, for 6 days, the …

The neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) produces
parkinsonian neurochemical and functional deficits in human and non-human primates. The …

The various biochemical mechanisms considered to explain the selective dopaminergic
neurotoxicity of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) are reviewed. MPTP …

Parkinson's disease (PD) is a neurodegenerative disease characterised by
histopathological and biochemical manifestations such as loss of midbrain dopaminergic …

We studied the microglial reaction in mice using the 1-methyl-4-phenyl-1, 2, 3, 6-
tetrahydropyridine (MPTP)-induced model for Parkinson's disease (PD). Microglial cells …