[HTML][HTML] Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP/PS1 mice

SM Day, SC Gironda, CW Clarke, JA Snipes… - Neurobiology of …, 2023 - Elsevier
Epidemiological studies identified alcohol use disorder (AUD) as a risk factor for Alzheimer's
disease (AD), yet there is conflicting evidence on how alcohol use promotes AD pathology …

[HTML][HTML] Chronic ethanol causes persistent increases in Alzheimer's tau pathology in female 3xTg-AD mice: a potential role for lysosomal impairment

AE Tucker, CM Alicea Pauneto, AM Barnett… - Frontiers in Behavioral …, 2022 - frontiersin.org
Epidemiological studies have found that heavy alcohol use is associated with increased risk
for Alzheimer's disease (AD)(Schwarzinger et al., 2018), with frequent drinking earlier in …

Ethanol alters APP processing and aggravates Alzheimer-associated phenotypes

D Huang, M Yu, S Yang, D Lou, W Zhou, L Zheng… - Molecular …, 2018 - Springer
The majority of Alzheimer's disease (AD) cases are sporadic with unknown causes. Many
dietary factors including excessive alcohol intake have been reported to increase the risk to …

Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease

JL Hoffman, S Faccidomo, M Kim, SM Taylor… - International review of …, 2019 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that represents the
most common cause of dementia in the United States. Although the link between alcohol …

Chronic intermittent ethanol exposure alters behavioral flexibility in aged rats compared to adult rats and modifies protein and protein pathways related to Alzheimer's …

AMC Ho, MP Peyton, SJ Scaletty, S Trapp… - ACS …, 2022 - ACS Publications
Repeated excessive alcohol consumption increases the risk of developing cognitive decline
and dementia. Hazardous drinking among older adults further increases such …

Adolescent binge alcohol enhances early Alzheimer's disease pathology in adulthood through proinflammatory neuroimmune activation

A Barnett, E David, A Rohlman, VD Nikolova… - Frontiers in …, 2022 - frontiersin.org
Epidemiological studies suggest that heavy alcohol use early in life is associated with
increased risk for Alzheimer's disease (AD). However, mechanisms connecting AD with …

Alcohol as a modifiable risk factor for alzheimer's disease—evidence from experimental studies

DV Chandrashekar, RA Steinberg, D Han… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive impairment and memory loss. Epidemiological evidence suggests that heavy …

Adolescent binge‐ethanol accelerates cognitive impairment and β‐amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE …

JC Ledesma, M Rodríguez‐Arias, AL Gavito… - Addiction …, 2021 - Wiley Online Library
Previous research in rodents suggests that the long‐term neurobehavioral disturbances
induced by chronic ethanol (EtOH) exposure could be due to endocannabinoid system …

Effects of Long-Term Alcohol Consumption on Behavior in the P301S (Line PS19) Tauopathy Mouse Model

CM Catavero, AE Marsh, AM Downs, AT Teklezghi… - bioRxiv, 2022 - biorxiv.org
Alcohol consumption and misuse remain prevalent public health issues with recent reports
of increased heavy consumption in older populations in the United States. Several studies …

Sex-specific effects of ethanol consumption in older Fischer 344 rats on microglial dynamics and Aβ (1-42) accumulation

P Marsland, AS Vore, EM DaPrano, JM Paluch… - Alcohol, 2023 - Elsevier
Chronic alcohol consumption, Alzheimer's disease (AD), and vascular dementia are all
associated with cognitive decline later in life, raising questions about whether their …