Metabolomic investigation of systemic manifestations associated with Alzheimer's disease in the APP/PS1 transgenic mouse model
R Gonzalez-Dominguez, T Garcia-Barrera… - Molecular …, 2015 - pubs.rsc.org
There is growing evidence that Alzheimer's disease may be a widespread systemic disorder,
so peripheral organs could be affected by pathological mechanisms occurring in this …
so peripheral organs could be affected by pathological mechanisms occurring in this …
Longitudinal investigation of neuroinflammation and metabolite profiles in the APPswe×PS1Δe9 transgenic mouse model of Alzheimer's disease
A Chaney, M Bauer, D Bochicchio… - Journal of …, 2018 - Wiley Online Library
There is increasing evidence linking neuroinflammation to many neurological disorders
including Alzheimer's disease (AD); however, its exact contribution to disease manifestation …
including Alzheimer's disease (AD); however, its exact contribution to disease manifestation …
Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer's disease
Alzheimer's disease is associated with various brain dysfunctions, including memory
impairment, neuronal loss, astrocyte activation, amyloid-β plaques, and neurofibrillary …
impairment, neuronal loss, astrocyte activation, amyloid-β plaques, and neurofibrillary …
Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease
PL Pugh, JC Richardson, ST Bate, N Upton… - Behavioural brain …, 2007 - Elsevier
Alzheimer's disease (AD) is characterised by progressive cognitive impairment with
neuropsychiatric symptoms such as anomalous motor behaviour, depression, anxiety …
neuropsychiatric symptoms such as anomalous motor behaviour, depression, anxiety …
Long-term treadmill exercise inhibits the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/PS1 transgenic mice
H Liu, G Zhao, H Zhang - Behavioural brain research, 2013 - Elsevier
Previously our study has demonstrated that long-term treadmill exercise improved cognitive
deficit in APP/PS1 transgenic mice of Alzheimer's disease (AD) paralleled by enhanced long …
deficit in APP/PS1 transgenic mice of Alzheimer's disease (AD) paralleled by enhanced long …
Progressive age‐related development of Alzheimer‐like pathology in APP/PS1 mice
F Trinchese, S Liu, F Battaglia, S Walter… - Annals of Neurology …, 2004 - Wiley Online Library
Increasing evidence points to synaptic plasticity impairment as one of the first events in
Alzheimer's disease (AD). However, studies on synaptic dysfunction in different transgenic …
Alzheimer's disease (AD). However, studies on synaptic dysfunction in different transgenic …
Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: a role for intraneuronal amyloid
L Gimenez-Llort, G Blazquez, T Canete… - Neuroscience & …, 2007 - Elsevier
The amyloid Aβ-peptide (Aβ) is suspected to play a critical role in the cascade leading to AD
as the pathogen that causes neuronal and synaptic dysfunction and, eventually, cell death …
as the pathogen that causes neuronal and synaptic dysfunction and, eventually, cell death …
Ethanol Exposure and Withdrawal Sensitizes the Rat Hippocampal CA1 Pyramidal Cell Region to β‐Amyloid (25‐35)‐Induced Cytotoxicity: NMDA Receptor …
RL Self, KJ Smith, PJ Mulholland… - Alcoholism: Clinical …, 2005 - Wiley Online Library
Background: Millions of Americans suffer from Alzheimer's Disease (AD), which is
characterized by significant neurological impairment and an accumulation in brain tissue of …
characterized by significant neurological impairment and an accumulation in brain tissue of …
Inflammasome-IL-1β signaling mediates ethanol inhibition of hippocampal neurogenesis
J Zou, FT Crews - Frontiers in neuroscience, 2012 - frontiersin.org
Regulation of hippocampal neurogenesis is poorly understood, but appears to contribute to
mood and cognition. Ethanol and neuroinflammation are known to reduce neurogenesis …
mood and cognition. Ethanol and neuroinflammation are known to reduce neurogenesis …
Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice
P Denver, A English, PL McClean - Brain, behavior, and immunity, 2018 - Elsevier
Cognitive dysfunction and neuroinflammation are typical in Alzheimer's disease (AD), but
are also associated with normal aging, albeit less severely. Insulin resistance in the brain …
are also associated with normal aging, albeit less severely. Insulin resistance in the brain …