Novel intravenous injectable TLR7 agonist, DSP-0509, synergistically enhanced antitumor immune responses in combination with anti-PD-1 antibody
Y Ota, T Otsubo, J Koroki, Y Hirose, E Koga-Yamakawa… - Cancer Research, 2018 - AACR
Toll-like receptors (TLRs) are a family of pattern-recognition receptors (PRR) that recognize
pathogen-associated molecular patterns (PAMPs). TLR7 is mainly expressed in …
pathogen-associated molecular patterns (PAMPs). TLR7 is mainly expressed in …
Toll‐Like Receptor‐Based Strategies for Cancer Immunotherapy
S Pahlavanneshan, A Sayadmanesh… - Journal of …, 2021 - Wiley Online Library
Toll‐like receptors (TLRs) are expressed and play multiple functional roles in a variety of
immune cell types involved in tumor immunity. There are plenty of data on the …
immune cell types involved in tumor immunity. There are plenty of data on the …
Is targeting Toll‐like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine‐driven inflammation?
E Andreakos, B Foxwell, M Feldmann - Immunological reviews, 2004 - Wiley Online Library
Cytokine‐driven inflammation and tissue destruction is a common theme of chronic
inflammatory diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis …
inflammatory diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis …
Expression and function of TLR2 on CD4 versus CD8 T cells
SM Lee, YD Joo, SK Seo - Immune network, 2009 - synapse.koreamed.org
Background Toll-like receptors (TLRs) play a fundamental role in innate immunity through
their capacity to recognize pathogen-associated molecular patterns. Also, TLRs that are …
their capacity to recognize pathogen-associated molecular patterns. Also, TLRs that are …
Role of toll-like receptor 4 (TLR4)-mediated interleukin-6 (IL-6) production in chemotherapy-induced mucositis
Despite significant advances in our ability to treat cancer, cytotoxic chemotherapy continues
to be the mainstay treatment for many solid tumours. Chemotherapy is commonly associated …
to be the mainstay treatment for many solid tumours. Chemotherapy is commonly associated …
Toll-like receptors as a therapeutic target in cancer, infections and inflammatory diseases
L Flórez-Álvarez, L Ruiz-Perez, N Taborda… - …, 2020 - Taylor & Francis
Toll-like receptors (TLRs) are widely expressed pattern recognition receptors that bind to
conserved molecular patterns expressed by pathogens and damaged cells. After …
conserved molecular patterns expressed by pathogens and damaged cells. After …
Positive T cell co-stimulation by TLR7/8 ligands is dependent on the cellular environment
D Richardt-Pargmann, M Wechsler, AM Krieg… - Immunobiology, 2011 - Elsevier
Toll-like receptors (TLRs) are mediators of innate immune responses detecting conserved
pathogen-associated molecules. Whereas most TLRs are expressed on the cell surface …
pathogen-associated molecules. Whereas most TLRs are expressed on the cell surface …
Toll-like receptor signaling and its role in cell-mediated immunity
Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
Trial Watch: Experimental Toll-like receptor agonists for cancer therapy
L Galluzzi, E Vacchelli, A Eggermont… - …, 2012 - Taylor & Francis
Toll-like receptors (TLRs) are prototypic pattern recognition receptors (PRRs) best known for
their ability to activate the innate immune system in response to conserved microbial …
their ability to activate the innate immune system in response to conserved microbial …
Toll like receptors signaling pathways as a target for therapeutic interventions
A Jezierska, IA Kolosova… - Current signal …, 2011 - ingentaconnect.com
This review summarizes the key role of Toll-Like Receptor (TLRs) molecules for igniting the
immune system. Activated by a broad spectrum of pathogens, cytokines or other specific …
immune system. Activated by a broad spectrum of pathogens, cytokines or other specific …