Transplant rejection remains a challenge especially in the field of vascularized composite
allotransplantation (VCA). To blunt the alloreactive immune response ‚stable levels of …

Although many key questions about Tregs remain, we are undoubtedly entering an exciting
era of Treg research in clinical transplantation. As renewed efforts focus on translational …

Numerous preclinical studies have provided solid evidence supporting adoptive transfer of
regulatory T cells (Tregs) to induce organ tolerance. As a result, there are 7 currently active …

T regulatory cells (Tregs) play a vital role in suppressing heightened immune response, and
thereby promote a state of immunological tolerance. Tregs modulate both innate and …

Optimizing regulatory T cells for therapeutic application in... : Current Opinion in Organ
Transplantation Optimizing regulatory T cells for therapeutic application in human organ …

The concept of regulatory T cell (Treg) therapy in transplantation is now a reality. Significant
advances in science and technology have enabled us to isolate human Tregs, expand them …

Regulatory T cells (Tregs) are essential to transplantation tolerance and their therapeutic
efficacy is well documented in animal models. Moreover, human Tregs can be identified …

Replacement of diseased organs with transplanted healthy donor ones remains the best
and often only treatment option for end-stage organ disease. Immunosuppressants have …

The induction of graft tolerance remains the holy grail of transplantation. This is important as
chronic allograft dysfunction and the side effects of immunosuppression regimens place a …

Adoptive regulatory T cell therapy: challenges in clinical t... : Current Opinion in Organ
Transplantation Adoptive regulatory T cell therapy: challenges in clinical transplantation : Current …