Regulatory T cells: liquid and living precision medicine for the future of VCA
M Kauke-Navarro, S Knoedler, AC Panayi… - …, 2023 - journals.lww.com
Transplant rejection remains a challenge especially in the field of vascularized composite
allotransplantation (VCA). To blunt the alloreactive immune response ‚stable levels of …
allotransplantation (VCA). To blunt the alloreactive immune response ‚stable levels of …
Regulatory T cells as therapeutic cells
P Sagoo, G Lombardi, RI Lechler - Current opinion in organ …, 2008 - journals.lww.com
Although many key questions about Tregs remain, we are undoubtedly entering an exciting
era of Treg research in clinical transplantation. As renewed efforts focus on translational …
era of Treg research in clinical transplantation. As renewed efforts focus on translational …
[HTML][HTML] Untangling the knots of regulatory T cell therapy in solid organ transplantation
G Orozco, M Gupta, R Gedaly, F Marti - Frontiers in Immunology, 2022 - frontiersin.org
Numerous preclinical studies have provided solid evidence supporting adoptive transfer of
regulatory T cells (Tregs) to induce organ tolerance. As a result, there are 7 currently active …
regulatory T cells (Tregs) to induce organ tolerance. As a result, there are 7 currently active …
[HTML][HTML] T regulatory cell-mediated immunotherapy for solid organ transplantation: a clinical perspective
MA Khan - Molecular Medicine, 2016 - Springer
T regulatory cells (Tregs) play a vital role in suppressing heightened immune response, and
thereby promote a state of immunological tolerance. Tregs modulate both innate and …
thereby promote a state of immunological tolerance. Tregs modulate both innate and …
Optimizing regulatory T cells for therapeutic application in human organ transplantation
T Vaikunthanathan, N Safinia… - Current Opinion in Organ …, 2018 - journals.lww.com
Optimizing regulatory T cells for therapeutic application in... : Current Opinion in Organ
Transplantation Optimizing regulatory T cells for therapeutic application in human organ …
Transplantation Optimizing regulatory T cells for therapeutic application in human organ …
Regulatory T cells: tolerance induction in solid organ transplantation
T Vaikunthanathan, N Safinia… - Clinical & …, 2017 - academic.oup.com
The concept of regulatory T cell (Treg) therapy in transplantation is now a reality. Significant
advances in science and technology have enabled us to isolate human Tregs, expand them …
advances in science and technology have enabled us to isolate human Tregs, expand them …
Regulatory T-cell therapy in transplantation: moving to the clinic
Q Tang, JA Bluestone - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
Regulatory T cells (Tregs) are essential to transplantation tolerance and their therapeutic
efficacy is well documented in animal models. Moreover, human Tregs can be identified …
efficacy is well documented in animal models. Moreover, human Tregs can be identified …
[HTML][HTML] Intragraft regulatory T cells in the modern era: what can high-dimensional methods tell us about pathways to allograft acceptance?
KF Bei, S Moshkelgosha, BJ Liu, S Juvet - Frontiers in Immunology, 2023 - frontiersin.org
Replacement of diseased organs with transplanted healthy donor ones remains the best
and often only treatment option for end-stage organ disease. Immunosuppressants have …
and often only treatment option for end-stage organ disease. Immunosuppressants have …
Regulatory T cells in solid organ transplantation
The induction of graft tolerance remains the holy grail of transplantation. This is important as
chronic allograft dysfunction and the side effects of immunosuppression regimens place a …
chronic allograft dysfunction and the side effects of immunosuppression regimens place a …
Adoptive regulatory T cell therapy: challenges in clinical transplantation
N Safinia, P Sagoo, R Lechler… - Current Opinion in Organ …, 2010 - journals.lww.com
Adoptive regulatory T cell therapy: challenges in clinical t... : Current Opinion in Organ
Transplantation Adoptive regulatory T cell therapy: challenges in clinical transplantation : Current …
Transplantation Adoptive regulatory T cell therapy: challenges in clinical transplantation : Current …