Glutathione is a low molecular weight thiol that is present at high levels in the cell. The high
levels of glutathione in the cell make it one of the most abundant antioxidants contributing to …

The interaction between antioxidant glutathione and the free thiol in susceptible cysteine
residues of proteins leads to reversible protein S-glutathionylation. This reaction ensures …

Redox homeostasis governs a number of critical cellular processes. In turn, imbalances in
pathways that control oxidative and reductive conditions have been linked to a number of …

S-glutathionylation, the post-translational modification forming mixed disulfides between
protein reactive thiols and glutathione, regulates redox-based signaling events in the cell …

The perturbation of thiol-disulfide homeostasis is an important consequence of many
diseases, with redox signals implicated in several physio-pathological processes. A …

Significance: Reactive oxygen and nitrogen species contributing to homeostatic regulation
and the pathogenesis of various cardiovascular diseases, including atherosclerosis …

Oxidative post-translational modifications (oxPTM) of receptors, enzymes, ion channels and
transcription factors play an important role in cell signaling. oxPTMs are a key way in which …

Glutathione has traditionally been considered as an antioxidant that protects cells against
oxidative stress. Hence, the loss of reduced glutathione and formation of glutathione …

Atherosclerosis is a chronic inflammatory disease involving the accumulation of monocytes
and macrophages in the vascular wall. Monocytes and macrophages play a central role in …

Cardiovascular diseases are the leading cause of death worldwide, and as rates continue to
increase, discovering mechanisms and therapeutic targets become increasingly important …