Xanthine oxidoreductase (XOR) is increased in the left ventricle (LV) of humans with volume
overload (VO), and mitochondrial inhibition of the respiratory chain occurs in animal models …

Xanthine oxidase (XO) is increased in human and rat left ventricular (LV) myocytes with
volume overload (VO) of mitral regurgitation and aortocaval fistula (ACF). In the setting of …

Left ventricular (LV) volume overload (VO) results in cardiomyocyte oxidative stress and
mitochondrial dysfunction. Because mitochondria are both a source and target of ROS, we …

After myocardial infarction, ventricular geometry and function, as well as energy metabolism,
change markedly. In nonischemic heart failure, inhibition of xanthine oxidase (XO) improves …

Inhibition of xanthine oxidase (XO) in failing hearts improves cardiac efficiency by an
unknown mechanism. We hypothesized that this energetic effect is due to reduced oxidative …

We hypothesized that chronic xanthine oxidase inhibition (XOI) would have favorable effects
on both ventricular and vascular performance in evolving heart failure (HF), thereby …

Aims Exercise intolerance in patients with heart failure (HF) is partly attributed to skeletal
muscle abnormalities. We have shown that reactive oxygen species (ROS) play a crucial …

Oxidative stress is a hallmark of systemic illnesses, including heart failure. Nevertheless, the
overall importance of radical production in the heart remains conjectural; is it merely a …

Aims Oxidative stress, ie imbalance between reactive oxygen species (ROS) and antioxidant
defences, contributes to the progression of chronic heart failure (CHF). Acute inhibition of …

Myocardial oxidative stress and Ca2+ overload induced by ischemia-reperfusion may be
involved in the development and progression of myocardial dysfunction in heart failure …