Figure. Effect of xanthine oxidase (XO) inhibition (XOI) on the nitroso-redox balance. The
underlying mechanistic basis for the use of XOIs in the failing heart. As shown, XOIs act on a …

Ischemia–reperfusion (IR) in the heart has been shown to produce myofibrillar remodeling
and depress Ca2+ sensitivity of myofilaments; however, the mechanisms for these …

We tested the hypothesis that pressure overload exacerbates oxidative stress associated
with augmented mitochondrial permeability transition (MPT) pore opening and cell death in …

Ischemic heart diseases (IHD) have become the leading cause of death around the world,
killing more than 7 million people annually. In IHD, the blockage of coronary vessels will …

Reactive oxygen species (ROS) play an important role in cardiovascular diseases, and one
important source for ROS are mitochondria. Emission of ROS from mitochondria is the net …

Mitochondria are important sites for the production of ATP and the generation of ROS in
cells. However, whether acute hypoxia increases ROS generation in cells or affects ATP …

In this chapter we analyze the onset of cardiac arrhythmias from the perspective of
mitochondrial redox state and energetic metabolism. Significant perturbations in the …

We have previously proposed that the heterogeneous collapse of mitochondrial inner
membrane potential (ΔΨm) during ischemia and reperfusion contributes to …

Mitochondria are an important source of reactive oxygen species (ROS), implicated in
ischemia/reperfusion injury. When isolated from ischemic myocardium, mitochondria …

The mitochondrial electron transport chain is the major source of reactive oxygen species
(ROS) during cardiac ischemia. Several mechanisms modulate ROS production; one is …