Respiratory muscle weakness resulting from both diaphragmatic contractile dysfunction and
atrophy has been hypothesized to contribute to the weaning difficulties associated with …

Mitochondria-generated reactive oxygen species (ROS) play a crucial role in the
pathogenesis of aging and age-associated diseases. In this study, we evaluated the effects …

Xanthine oxidase (XO) activity contributes to both abnormal excitation-contraction (EC)
coupling and cardiac remodeling in heart failure (HF). β-Adrenergic hyporesponsiveness …

Background: Cardiovascular diseases (CVDs) are a leading risk factor for mortality
worldwide and the number of CVDs victims is predicted to rise through 2030. While several …

Mitochondria produce and scavenge reactive oxygen species (ROS); however, whether
oxidative distress due to exogenous stress arises from excessive production or impaired …

Xanthine oxidoreductase (XOR) plays a prominent role in acute lung injury because of its
ability to generate reactive oxygen species. We investigated the role of XOR in ventilator …

Background: This study was designed to investigate the role of a primary hyperoxidative
stress in myocardial electrical remodeling using heterozygous heart/muscle-specific …

Pharmacologic cardiac conditioning increases the intrinsic resistance against ischemia and
reperfusion (I/R) injury. The cardiac conditioning response is mediated via complex …

Mitochondria are critical modulators of cell function and are increasingly recognized as
proximal sensors and effectors that ultimately determine the balance between cell survival …

Using a highly specific assay that minimizes enzyme inactivation in vitro, we found that
rabbit myocardial tissue contained low levels of xanthine oxidase (XO) and xanthine …