Zebrafish (Danio rerio) is a valuable non-mammalian vertebrate model widely used to study
development and disease, including more recently cancer. The evolutionary conservation of …

Simple Summary The identification and development of new anti-cancer drugs requires
extensive testing in animal models to establish safety and efficacy of drug candidates. The …

Introduction: Patients with metastatic cancer suffer the highest rate of cancer-related death,
but existing animal models of metastasis have disadvantages that limit our ability to …

Animal xenografts of human cancers represent a key preclinical tool in the field of cancer
research. While mouse xenografts have long been the gold standard, investigators have …

The zebrafish is a recent addition to animal models of human cancer, and studies using this
model are rapidly contributing major insights. Zebrafish develop cancer spontaneously, after …

In an era of high-throughput “omic” technologies, the unprecedented amount of data that can
be generated presents a significant opportunity but simultaneously an even greater …

First established as a valuable vertebrate model system for studying development, zebrafish
have emerged as an attractive animal system for modeling human cancers. Major technical …

Firmly established as a model system for development, the zebrafish is now emerging as an
effective system for the study of the fundamental aspects of tumorigenesis. In keeping with …

For the last three decades significant parts of national science budgets, and international
and private funding worldwide, have been dedicated to cancer research. This has resulted …

The zebrafish has become a powerful vertebrate model for genetic studies of embryonic
development and organogenesis and increasingly for studies in cancer biology. Zebrafish …