Background Use of third-generation cephalosporins, such as cefotaxime, is associated with
an increased risk of selection for antimicrobial resistance, so alternative antibiotics need to …

Background Temocillin is an old 'revived'antibiotic that may play an important role in the
treatment of febrile urinary tract infection (UTI). Data regarding its activity against current …

Background Gepotidacin is a novel, bactericidal, first-in-class triazaacenaphthylene
antibiotic that inhibits bacterial DNA replication by a distinct mechanism of action and a …

Background Treatment of complicated urinary-tract infections is challenging due to rising
antimicrobial resistance. We assessed the efficacy and safety of ceftolozane-tazobactam, a …

Background A reduction in duration of antibiotic therapy is crucial in minimizing the
development of antimicrobial resistance, drug-related side effects and health care costs. The …

Importance The consumption of broad-spectrum drugs has increased as a consequence of
the spread of multidrug-resistant (MDR) Escherichia coli. Finding alternatives for these …

Importance Meropenem-vaborbactam is a combination carbapenem/beta-lactamase
inhibitor and a potential treatment for severe drug-resistant gram-negative infections …

Objectives To compare the efficacy of temocillin with carbapenems for extended spectrum β-
lactamase (ESBL)-producing Enterobacteriaceae urinary tract infections (ESBL-E UTI) …

Background The role of oral beta-lactam antibiotics in treating febrile urinary tract infections
(UTI) is not yet definite. Today, fluoroquinolones together with trimethoprim …

Background Uncomplicated urinary tract infections in women are common, and urine
samples from these patients are not routinely cultured. Empirical treatment is based on …