Multicenter, double-blind, randomized, phase II trial to assess the safety and efficacy of ceftolozane-tazobactam plus metronidazole compared with meropenem in …

C Lucasti, E Hershberger, B Miller… - Antimicrobial agents …, 2014 - Am Soc Microbiol
ABSTRACT Ceftolozane-tazobactam (TOL-TAZ) is a novel antibacterial with activity against
Pseudomonas aeruginosa and other common Gram-negative pathogens, including …

[HTML][HTML] Biomarker guided triage can reduce hospitalization rate in community acquired febrile urinary tract infection

JE Stalenhoef, C van Nieuwkoop, DC Wilson… - Journal of Infection, 2018 - Elsevier
Objectives Febrile urinary tract infections (fUTI) can often be treated safely with oral
antimicrobials in an outpatient setting. However, a minority of patients develop complications …

Methenamine hippurate to prevent recurrent urinary tract infections in older women: protocol for a randomised, placebo-controlled trial (ImpresU)

SR Heltveit-Olsen, PD Sundvall, R Gunnarsson… - BMJ open, 2022 - bmjopen.bmj.com
Introduction Methenamine hippurate is a urinary antiseptic used as preventive treatment for
recurrent urinary tract infections (UTIs) in some Scandinavian countries. However, the …

A multicenter, randomized, double-blind, phase 2 study of the efficacy and safety of plazomicin compared with levofloxacin in the treatment of complicated urinary tract …

LE Connolly, V Riddle, D Cebrik… - Antimicrobial Agents …, 2018 - Am Soc Microbiol
Increasing antimicrobial resistance among uropathogens limits treatment options for patients
with complicated urinary tract infection (cUTI). Plazomicin, a new aminoglycoside, has in …

Assessment of empirical antibiotic therapy optimisation in six hospitals: an observational cohort study

NP Braykov, DJ Morgan, ML Schweizer… - The Lancet Infectious …, 2014 - thelancet.com
Background Modification of empirical antimicrobials when warranted by culture results or
clinical signs is recommended to control antimicrobial overuse and resistance. We aimed to …

[HTML][HTML] Carbapenems vs alternative antibiotics for the treatment of complicated urinary tract infection: A systematic review and network meta-analysis

X Tan, Q Pan, C Mo, X Li, X Liang, Y Li, Y Lan, L Chen - Medicine, 2020 - journals.lww.com
Background: Complicated urinary tract infections (cUTI) are universal reasons for
hospitalization, and highly likely to develop into sepsis or septic shock. Carbapenem …

Preventing sepsis development in complicated urinary tract infections

N Petrosillo, G Granata, B Boyle, MM Doyle… - Expert Review of Anti …, 2020 - Taylor & Francis
ABSTRACT Introduction: Urinary tract infections (UTIs) are the most prevalent infections in
the community and the most common reason for antimicrobial prescribing in ambulatory …

[HTML][HTML] Retrospective evaluation of nitrofurantoin and pivmecillinam for the treatment of lower urinary tract infections in men

H Montelin, KJ Forsman, T Tängdén - PLoS One, 2019 - journals.plos.org
Objectives This study aimed to retrospectively assess the clinical outcome with nitrofurantoin
and pivmecillinam for lower urinary tract infections (UTI) in men. Patients treated with …

Sulopenem or ciprofloxacin for the treatment of uncomplicated urinary tract infections in women: a phase 3, randomized trial

MW Dunne, SI Aronin, AF Das… - Clinical Infectious …, 2023 - academic.oup.com
Background There are limited treatment options for uncomplicated urinary tract infection
(uUTI) caused by resistant pathogens. Sulopenem etzadroxil/probenecid (sulopenem) is an …

[HTML][HTML] A global perspective on improving patient care in uncomplicated urinary tract infection: expert consensus and practical guidance

F Wagenlehner, L Nicolle, R Bartoletti, AC Gales… - Journal of global …, 2022 - Elsevier
Objectives Uncomplicated urinary tract infections (uUTIs) are a common problem in female
patients. Management is mainly based on empirical prescribing, but there are concerns …