The tumour microenvironment in pancreatic cancer—clinical challenges and opportunities

WJ Ho, EM Jaffee, L Zheng - Nature reviews Clinical oncology, 2020 - nature.com
Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumours
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …

The tumor microenvironment in pancreatic ductal adenocarcinoma: current perspectives and future directions

CJ Herting, I Karpovsky, GB Lesinski - Cancer and Metastasis Reviews, 2021 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies and is
characterized by a unique tumor microenvironment (TME) consisting of an abundant stromal …

The pancreatic cancer microenvironment

SK Dougan - The Cancer Journal, 2017 - journals.lww.com
Pancreatic ductal adenocarcinoma (PDAC) is composed of a minority of malignant cells
within a microenvironment of extracellular matrix, fibroblasts, endothelial cells, and immune …

[HTML][HTML] The paradoxical web of pancreatic cancer tumor microenvironment

KJ Lafaro, LG Melstrom - The American journal of pathology, 2019 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is increasing in incidence and is projected to
become the second leading cause of cancer death in the United States. Despite significant …

Pancreatic cancer microenvironment and cellular composition: current understandings and therapeutic approaches

LH Truong, S Pauklin - Cancers, 2021 - mdpi.com
Simple Summary There is currently no effective treatment for Pancreatic Ductal
Adenocarcinoma (PDAC), and it is still the deadliest cancer, despite great research efforts in …

The pancreas cancer microenvironment

C Feig, A Gopinathan, A Neesse, DS Chan, N Cook… - Clinical cancer …, 2012 - AACR
Pancreatic ductal adenocarcinoma (PDA) is a common and lethal malignancy resulting in
more than 250,000 deaths per year worldwide. Despite extensive efforts, cytotoxic and …

Stromal biology and therapy in pancreatic cancer: ready for clinical translation?

A Neesse, CA Bauer, D Öhlund, M Lauth, M Buchholz… - Gut, 2019 - gut.bmj.com
Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The
tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote …

Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma

A Neesse, S Krug, TM Gress, DA Tuveson… - OncoTargets and …, 2013 - Taylor & Francis
Pancreatic ductal adenocarcinoma is a stroma-rich and highly challenging cancer to treat.
Over recent years, it has become increasingly evident that the complex network of soluble …

Tumor microenvironment in pancreatic cancer pathogenesis and therapeutic resistance

MH Sherman, GL Beatty - Annual Review of Pathology …, 2023 - annualreviews.org
Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment
with remarkable cellular and spatial heterogeneity that meaningfully impacts disease …

Tumor immune microenvironment-based therapies in pancreatic ductal adenocarcinoma: time to update the concept

W Luo, T Wen, X Qu - Journal of Experimental & Clinical Cancer Research, 2024 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumors. The tumor
immune microenvironment (TIME) formed by interactions among cancer cells, immune cells …