The tumour microenvironment in pancreatic cancer—clinical challenges and opportunities
WJ Ho, EM Jaffee, L Zheng - Nature reviews Clinical oncology, 2020 - nature.com
Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumours
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …
The tumor microenvironment in pancreatic ductal adenocarcinoma: current perspectives and future directions
CJ Herting, I Karpovsky, GB Lesinski - Cancer and Metastasis Reviews, 2021 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies and is
characterized by a unique tumor microenvironment (TME) consisting of an abundant stromal …
characterized by a unique tumor microenvironment (TME) consisting of an abundant stromal …
The pancreatic cancer microenvironment
SK Dougan - The Cancer Journal, 2017 - journals.lww.com
Pancreatic ductal adenocarcinoma (PDAC) is composed of a minority of malignant cells
within a microenvironment of extracellular matrix, fibroblasts, endothelial cells, and immune …
within a microenvironment of extracellular matrix, fibroblasts, endothelial cells, and immune …
[HTML][HTML] The paradoxical web of pancreatic cancer tumor microenvironment
KJ Lafaro, LG Melstrom - The American journal of pathology, 2019 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is increasing in incidence and is projected to
become the second leading cause of cancer death in the United States. Despite significant …
become the second leading cause of cancer death in the United States. Despite significant …
Pancreatic cancer microenvironment and cellular composition: current understandings and therapeutic approaches
LH Truong, S Pauklin - Cancers, 2021 - mdpi.com
Simple Summary There is currently no effective treatment for Pancreatic Ductal
Adenocarcinoma (PDAC), and it is still the deadliest cancer, despite great research efforts in …
Adenocarcinoma (PDAC), and it is still the deadliest cancer, despite great research efforts in …
The pancreas cancer microenvironment
C Feig, A Gopinathan, A Neesse, DS Chan, N Cook… - Clinical cancer …, 2012 - AACR
Pancreatic ductal adenocarcinoma (PDA) is a common and lethal malignancy resulting in
more than 250,000 deaths per year worldwide. Despite extensive efforts, cytotoxic and …
more than 250,000 deaths per year worldwide. Despite extensive efforts, cytotoxic and …
Stromal biology and therapy in pancreatic cancer: ready for clinical translation?
A Neesse, CA Bauer, D Öhlund, M Lauth, M Buchholz… - Gut, 2019 - gut.bmj.com
Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The
tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote …
tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote …
Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma
A Neesse, S Krug, TM Gress, DA Tuveson… - OncoTargets and …, 2013 - Taylor & Francis
Pancreatic ductal adenocarcinoma is a stroma-rich and highly challenging cancer to treat.
Over recent years, it has become increasingly evident that the complex network of soluble …
Over recent years, it has become increasingly evident that the complex network of soluble …
Tumor microenvironment in pancreatic cancer pathogenesis and therapeutic resistance
MH Sherman, GL Beatty - Annual Review of Pathology …, 2023 - annualreviews.org
Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment
with remarkable cellular and spatial heterogeneity that meaningfully impacts disease …
with remarkable cellular and spatial heterogeneity that meaningfully impacts disease …
Tumor immune microenvironment-based therapies in pancreatic ductal adenocarcinoma: time to update the concept
W Luo, T Wen, X Qu - Journal of Experimental & Clinical Cancer Research, 2024 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumors. The tumor
immune microenvironment (TIME) formed by interactions among cancer cells, immune cells …
immune microenvironment (TIME) formed by interactions among cancer cells, immune cells …