[HTML][HTML] Celecoxib enhances radiosensitivity via induction of G2-M phase arrest and apoptosis in nasopharyngeal carcinoma

S Zhang, Q Qiu, W Chen, C Liang… - Cellular Physiology and …, 2014 - karger.com
Background: Previous work has proposed that celecoxib may be able to enhance the effects
of radiotherapy. However, the underlying mechanism of this activity has not yet been …

Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and …

P Zhang, D He, E Song, M Jiang, Y Song - PLoS One, 2019 - journals.plos.org
The current study aimed to identify the radiosensitizing effect of celecoxib, a selective
cyclooxygenase-2 (COX-2) inhibitor, in combination with radiotherapy in non-small-cell lung …

Radiosensitivity enhancement by Celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, via COX-2–dependent cell cycle regulation on human cancer cells …

YK Shin, JS Park, HS Kim, HJ Jun, GE Kim, CO Suh… - Cancer research, 2005 - AACR
To characterize the radiation-enhancing effects on human cancer cells and underlying
mechanisms of celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, and to ascertain …

Different cell cycle modulation by celecoxib at different concentrations

YM Kim, H Pyo - Cancer Biotherapy and Radiopharmaceuticals, 2013 - liebertpub.com
Abstract Different cyclooxygenase (COX)-2 inhibitors were known to cause different cell
cycle changes. We investigated whether this different effect on cell cycle change was due to …

Celecoxib radiosensitizes the human cervical cancer HeLa cell line via a mechanism dependent on reduced cyclo-oxygenase-2 and vascular endothelial growth …

AH Wang, XY Tian, JJ Yu, JQ Mi… - Journal of …, 2012 - journals.sagepub.com
OBJECTIVE: The effects of celecoxib, a selective cyclo-oxygenase-2 (COX-2) inhibitor, on
HeLa cervical cancer cell growth and radiosensitivity were investigated. METHODS …

Anti-cancer effects of celecoxib on nasopharyngeal carcinoma HNE-1 cells expressing COX-2 oncoprotein

J Chen, Y Ran, C Hong, Z Chen, Y You - Cytotechnology, 2010 - Springer
Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor with antitumor and
antiangiogenic activities. To investigate the effects of celecoxib on nasopharyngeal …

Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation

D Liu, G Hu, G Long, H Qiu, Q Mei, G Hu - Acta Pharmacologica Sinica, 2012 - nature.com
Aim: To investigate the mechanisms underlying the anticancer effect of celecoxib on
nasopharyngeal carcinoma (NPC). Methods: NPC cell lines, HNE1 and CNE1-LMP1, were …

Inhibition of cyclooxygenase‑2 sensitizes lung cancer cells to radiation‑induced apoptosis Corrigendum in/10.3892/ol. 2019.10268

ZQ Han, H Liao, F Shi, XP Chen, HC Hu… - Oncology …, 2017 - spandidos-publications.com
Radiotherapy resistance is an enduring major setback in lung cancer therapy, and is
responsible for a large proportion of treatment failures. In previous years, cyclooxygenase‑2 …

Celecoxib enhances the inhibitory effect of 5‐FU on human squamous cell carcinoma proliferation by ROS production

MW Sung, DY Lee, SW Park, SM Oh, JJ Choi… - The …, 2017 - Wiley Online Library
Objectives The role of celecoxib in preventing and treating tumors has attracted broad
attention in recent years because of its selective and specific inhibition of COX‐2 activity. We …

Celecoxib-erlotinib combination treatment enhances radiosensitivity in A549 human lung cancer cell

J Sun, NB Liu, HQ Zhuang, LJ Zhao… - Cancer …, 2017 - content.iospress.com
BACKGROUND: Radiosensitivity by blocking the epidermal growth factor receptor and
cyclooxygenase-2 pathways with erlotinib and celecoxib in A549 human lung cancer cell …