[HTML][HTML] Altered immune response to the epstein–barr virus as a prerequisite for multiple sclerosis

F Läderach, C Münz - Cells, 2022 - mdpi.com
Strong epidemiologic evidence links Epstein–Barr virus (EBV) infection and its altered
immune control to multiple sclerosis (MS) development. Clinical MS onset occurs years after …

MINI-review of Epstein-Barr virus involvement in multiple sclerosis etiology and pathogenesis

F Aloisi, AH Cross - Journal of Neuroimmunology, 2022 - Elsevier
Epstein-Barr virus (EBV) is the infectious agent that shows the strongest association with
multiple sclerosis (MS). EBV is a ubiquitous double stranded DNA herpes virus that …

[HTML][HTML] Epstein-Barr virus and multiple sclerosis

G Houen, NH Trier, JL Frederiksen - Frontiers in immunology, 2020 - frontiersin.org
Multiple sclerosis (MS) is a neurologic disease affecting myelinated nerves in the central
nervous system (CNS). The disease often debuts as a clinically isolated syndrome, eg, optic …

The association of Epstein‐Barr virus infection with CXCR3+ B‐cell development in multiple sclerosis: impact of immunotherapies

J van Langelaar, AF Wierenga‐Wolf… - European journal of …, 2021 - Wiley Online Library
Epstein–Barr virus (EBV) infection of B cells is associated with increased multiple sclerosis
(MS) susceptibility. Recently, we found that CXCR3‐expressing B cells preferentially …

[HTML][HTML] Multiple sclerosis-like symptoms in mice are driven by latent γHerpesvirus-68 infected b cells

AC Márquez, I Shanina, MS Horwitz - Frontiers in Immunology, 2020 - frontiersin.org
Multiple sclerosis (MS) is caused by a combination of genetic and environmental factors. It is
believed that previous infection with Epstein Barr Virus (EBV) plays an important role in the …

Epstein–Barr virus and multiple sclerosis: potential opportunities for immunotherapy

MP Pender, SR Burrows - Clinical & translational immunology, 2014 - Wiley Online Library
Multiple sclerosis (MS) is a common chronic inflammatory demyelinating disease of the
central nervous system (CNS) causing progressive disability. Many observations implicate …

[HTML][HTML] The CD8 T cell-Epstein-Barr virus-B cell trialogue: a central issue in multiple sclerosis pathogenesis

C Veroni, F Aloisi - Frontiers in immunology, 2021 - frontiersin.org
The cause and the pathogenic mechanisms leading to multiple sclerosis (MS), a chronic
inflammatory disease of the central nervous system (CNS), are still under scrutiny. During …

The elimination of circulating Epstein-Barr virus infected B cells underlies anti-CD20 monoclonal antibody activity in multiple sclerosis: A hypothesis

JR Berger, M Kakara - Multiple Sclerosis and Related Disorders, 2022 - Elsevier
Multiple sclerosis is a chronic immune-mediated disease of the central nervous system that
has aspects of repetitive inflammatory activity as well as a slow neurodegenerative process …

Analysis of the cross‐talk of Epstein–Barr virus‐infected B cells with T cells in the marmoset

J Dunham, N Van Driel, BJL Eggen… - Clinical & …, 2017 - Wiley Online Library
Despite the well‐known association of Epstein–Barr virus (EBV), a lymphocryptovirus (LCV),
with multiple sclerosis, a clear pathogenic role for disease progression has not been …

[HTML][HTML] Epstein Barr virus exploits genetic susceptibility to increase multiple sclerosis risk

F Läderach, C Münz - Microorganisms, 2021 - mdpi.com
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) for
which both genetic and environmental risk factors have been identified. The strongest …