Experimental autoimmune encephalomyelitis (EAE) in outbred marmoset monkeys
(Callithrix jacchus) is a recently developed nonhuman primate model of multiple sclerosis …

New treatments for multiple sclerosis (MS) focused on B cells have created an atmosphere
of excitement in the MS community. B cells are now known to play a major role in disease …

MS is widely considered to be a T cell-mediated disease although T cell immunotherapy has
consistently failed, demonstrating distinct differences with experimental autoimmune …

Epstein-Barr virus (EBV) is one of the most common and successful human viruses, infecting
more than 90% of the world's adult population. Despite its strong tumorigenic potential, most …

Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive
lymphocytes attack the myelin sheath of the central nervous system. B lymphocytes in the …

Highlights•We developed a valid preclinical model for chronic MS in marmosets.•The model
displays pathological aspects of progressive MS in cortical grey matter.•The model shows a …

Background and Objectives Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that
establishes lifelong latency in memory B cells and has been identified as a major risk factor …

Abstract The link between Epstein–Barr virus (EBV) and multiple sclerosis (MS) has puzzled
researchers since it was first discovered over 40 years ago. Until that point, EBV was …

This study investigated the effect of CD20-positive B-cell depletion on central nervous
system (CNS) white and gray matter pathology in experimental autoimmune …

Epstein-Barr virus (EBV) is a ubiquitous herpesvirus strongly associated with multiple
sclerosis (MS), a chronic inflammatory disease of the central nervous system (CNS) …