Epstein–Barr virus (EBV) is an aetiologic risk factor for the development of multiple sclerosis
(MS). However, the role of EBV-infected B cells in the immunopathology of MS is not well …

CD40‐CD40 ligand interactions are crucial to cognate interactions between T cells, B cells
and antigen‐presenting cells (APC), and contribute to non‐antigen‐specific effector …

The robust and rapid clinical effect of depleting anti-CD20 monoclonal antibodies (mAb) in
multiple sclerosis (MS) demonstrates a critical pathogenic contribution of B cells. The clinical …

Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …

In view of disease heterogeneity of multiple sclerosis and limited access to ex vivo
specimens, different approaches must be undertaken to better understand disease …

The efficacy of B cell depletion therapy in multiple sclerosis indicates their central
pathogenic role in disease pathogenesis. The B lymphotropic EBV is a major risk factor in …

Abstract Background Epstein‐Barr Virus (EBV) is strongly associated with multiple sclerosis
(MS). After initial infection, EBV maintains a life‐long latent infection in B lymphocytes …

In contrast to previous smaller studies, Aloisi and colleagues have recently reported the
presence of large numbers of Epstein–Barr virus (EBV) infected B cells in the brains of a …

Background B cell depletion therapy is highly effective in relapsing-remitting multiple
sclerosis (RRMS). However, the precise underlying mechanisms of action for its biological …

Autoimmune diseases of the central nervous system (CNS) such as multiple sclerosis (MS)
are only partially represented in current experimental models and the development of …