The concentrations of antibodies to Epstein-Barr virus decrease during ocrelizumab treatment

HPT Pham, S Saroukhani, JW Lindsey - Multiple Sclerosis and Related …, 2023 - Elsevier
Abstract Background Epstein‐Barr Virus (EBV) is strongly associated with multiple sclerosis
(MS). After initial infection, EBV maintains a life‐long latent infection in B lymphocytes …

[HTML][HTML] Navigating Epstein–Barr virus autoimmunity: role of NK cells and T cells in multiple sclerosis

C Xie, C Sun, MS Zeng - Signal Transduction and Targeted Therapy, 2024 - nature.com
In a recent study published in Cell, Vietzen and colleagues discovered the novel role of
natural killer (NK) cells and EBV-specific CD8+ T cell response in controlling EBV-inducing …

CD8+ T cell help is required for efficient induction of EAE in Lewis rats

M Camara, N Beyersdorf, HJ Fischer, MJ Herold… - Journal of …, 2013 - Elsevier
The role of CD8+ T cells in multiple sclerosis (MS) and experimental autoimmune
encephalomyelitis (EAE) is still unclear. We describe here significantly reduced disease …

[HTML][HTML] Heightened Epstein-Barr virus immunity and potential cross-reactivities in multiple sclerosis

OG Thomas, TA Haigh, D Croom-Carter… - PLoS …, 2024 - journals.plos.org
Background Epstein-Barr virus (EBV) is a likely prerequisite for multiple sclerosis (MS) but
the underlying mechanisms are unknown. We investigated antibody and T cell responses to …

B cell antigen presentation is sufficient to drive neuroinflammation in an animal model of multiple sclerosis

CR Parker Harp, AS Archambault, J Sim… - The Journal of …, 2015 - journals.aai.org
B cells are increasingly regarded as integral to the pathogenesis of multiple sclerosis, in part
as a result of the success of B cell–depletion therapy. Multiple B cell–dependent …

Epstein–Barr virus and multiple sclerosis: causation or association?

K Kakalacheva, M Comabella - Future microbiology, 2010 - Taylor & Francis
Editorial Kakalacheva & Comabella found to be significantly elevated in patients with CIS
compared with patients with relapsing-remitting and progressive forms of MS and healthy …

[HTML][HTML] Involvement of age-associated B cells in EBV-triggered autoimmunity

A Sachinidis, A Garyfallos - Immunologic research, 2022 - Springer
EBV infection has long been suspected to play a role in the development of autoimmune
diseases. Interestingly, a recently published study has provided the strongest evidence to …

EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2

JD Lünemann, I Jelčić, S Roberts… - The Journal of …, 2008 - rupress.org
Symptomatic primary Epstein-Barr virus (EBV) infection and elevated humoral immune
responses to EBV are associated with an increased risk of developing multiple sclerosis …

B‐cell activation influences T‐cell polarization and outcome of anti‐CD20 B‐cell depletion in central nervous system autoimmunity

MS Weber, T Prod'Homme, JC Patarroyo… - Annals of …, 2010 - Wiley Online Library
Objective Clinical studies indicate that anti‐CD20 B‐cell depletion may be an effective
multiple sclerosis (MS) therapy. We investigated mechanisms of anti‐CD20‐mediated …

Frequency analysis of HLA-B7-restricted Epstein-Barr virus-specific cytotoxic T lymphocytes in patients with multiple sclerosis and healthy controls

F Gronen, K Ruprecht, B Weissbrich, E Klinker… - Journal of …, 2006 - Elsevier
The Epstein-Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis
(MS), however, the mechanisms by which EBV may be involved in MS are unknown. We …