Viral carrier transport efficiency of gene delivery is high, depending on the type of vector.
However, viral delivery poses significant safety concerns such as inefficient/unpredictable …

Bone tissue loss as a consequence of the natural aging process or as a result of trauma and
degenerative disease has led to the need for procedures to generate cartilage and bone for …

Recent advances in the approval and commercialization of gene therapeutics have fostered
the return of gene therapy to center stage. But despite new optimism, no Food and Drug …

Strategies for delivering nucleic acids into damaged and diseased tissues have been
divided into two major areas: viral and non-viral gene therapy. In this mini-review article we …

Background: Viral vector-based therapeutic gene therapy is a potent strategy to enhance the
intrinsic reparative abilities of human orthopaedic tissues. However, clinical application of …

Mesenchymal stem cells (MSCs) can be isolated from several tissues in the body, have the
ability to selfrenewal, show immune suppressive properties and are multipotent, being able …

Highlights•Focus on disease-modifying approaches for intra-articular drug
delivery.•Polymeric particles as platforms for sustained and controlled drug release.•In vivo …

Gene therapy has converged with bone engineering over the past decade, by which a
variety of therapeutic genes have been delivered to stimulate bone repair. These genes can …

Heretofore, nonviral methods have been used primarily for in vitro transfection of cultured
cell lines. These methods were substantially less efficient when compared with the use of …

In orthopaedics, gene-based treatment approaches are being investigated for an array of
common-yet medically challenging-pathologic conditions of the skeletal connective tissues …