Mitochondrial Dysfunction in Periodontitis and Associated Systemic Diseases: Implications for Pathomechanisms and Therapeutic Strategies
Y Deng, J Xiao, L Ma, C Wang, X Wang… - International Journal of …, 2024 - mdpi.com
Periodontitis is a chronic infectious disorder damaging periodontal tissues, including the
gingiva, periodontal ligament, cementum, and alveolar bone. It arises from the complex …
gingiva, periodontal ligament, cementum, and alveolar bone. It arises from the complex …
The role of mitochondrial dysfunction in periodontitis: From mechanisms to therapeutic strategy
W Jiang, Y Wang, Z Cao, Y Chen, C Si… - Journal of …, 2023 - Wiley Online Library
Periodontitis is an inflammatory and destructive disease of tooth‐supporting tissue and has
become the leading cause of adult tooth loss. The most central pathological features of …
become the leading cause of adult tooth loss. The most central pathological features of …
Mitochondria: An Emerging Unavoidable Link in the Pathogenesis of Periodontitis Caused by Porphyromonas gingivalis
S Luo, T Xu, Q Zheng, A Jiang, J Zhao, Y Ying… - International Journal of …, 2024 - mdpi.com
Porphyromonas gingivalis (P. gingivalis) is a key pathogen of periodontitis. Increasing
evidence shows that P. gingivalis signals to mitochondria in periodontal cells, including …
evidence shows that P. gingivalis signals to mitochondria in periodontal cells, including …
Mitochondrial dysfunction in the pathogenesis and treatment of Oral inflammatory diseases
Z Dong, L Wu, H Hong - International Journal of Molecular Sciences, 2023 - mdpi.com
Oral inflammatory diseases (OIDs) include many common diseases such as periodontitis
and pulpitis. The causes of OIDs consist microorganism, trauma, occlusal factors …
and pulpitis. The causes of OIDs consist microorganism, trauma, occlusal factors …
Mitochondrial dysfunction is involved in the aggravation of periodontitis by diabetes
X Sun, Y Mao, P Dai, X Li, W Gu… - Journal of Clinical …, 2017 - Wiley Online Library
Aim To elucidate whether mitochondrial dysfunction contributes to aggravated periodontitis
in diabetes. Materials and Methods Sixty‐four wistar rats were randomly assigned into four …
in diabetes. Materials and Methods Sixty‐four wistar rats were randomly assigned into four …
Mitochondrial homeostasis in odontoblast: Physiology, pathogenesis and targeting strategies
X Meng, H Mao, M Wan, L Lu, Z Chen, L Zhang - Life Sciences, 2024 - Elsevier
Caries and pulpitis remain a major global disease burden and affect the quality of life of
patients. Odontoblasts are key players in the progression of caries and pulpitis, not only …
patients. Odontoblasts are key players in the progression of caries and pulpitis, not only …
Integrated machine learning and Bioinformatic analyses constructed a network between mitochondrial dysfunction and immune microenvironment of periodontitis
H Chen, L Peng, Z Wang, Y He, X Zhang - Inflammation, 2023 - Springer
Periodontitis is a prevalent and persistent inflammatory condition that impacts the supporting
tissues of the teeth, including the gums and bone. Recent research indicates that …
tissues of the teeth, including the gums and bone. Recent research indicates that …
Abnormal mitochondrial structure and function are retained in gingival tissues and human gingival fibroblasts from patients with chronic periodontitis
J Liu, X Wang, F Xue, M Zheng… - Journal of periodontal …, 2022 - Wiley Online Library
Abstract Background and Objective The abnormal structure and function of mitochondria in
cells is closely associated with inflammatory diseases. However, the physiology of …
cells is closely associated with inflammatory diseases. However, the physiology of …
Mitochondrial dysfunction and genetic heterogeneity in chronic periodontitis
We performed an extensive study on mitochondrial dysfunction in chronic periodontitis (CP).
Electron microscopic analysis of gingival cells revealed abnormal mitochondria in 60% of …
Electron microscopic analysis of gingival cells revealed abnormal mitochondria in 60% of …
Integrated analyses revealed the potential role and immune link of mitochondrial dysfunction between periodontitis and type 2 diabetes mellitus
S Pan, LX Yang, W Zhong, H Wang, Y Lan… - International …, 2024 - Elsevier
There is a reciprocal comorbid relationship between periodontitis and type 2 diabetes
mellitus (T2DM). Recent studies have suggested that mitochondrial dysfunction (MD) could …
mellitus (T2DM). Recent studies have suggested that mitochondrial dysfunction (MD) could …