Mitochondrial Dysfunction in Periodontitis and Associated Systemic Diseases: Implications for Pathomechanisms and Therapeutic Strategies

Y Deng, J Xiao, L Ma, C Wang, X Wang… - International Journal of …, 2024 - mdpi.com
Periodontitis is a chronic infectious disorder damaging periodontal tissues, including the
gingiva, periodontal ligament, cementum, and alveolar bone. It arises from the complex …

The role of mitochondrial dysfunction in periodontitis: From mechanisms to therapeutic strategy

W Jiang, Y Wang, Z Cao, Y Chen, C Si… - Journal of …, 2023 - Wiley Online Library
Periodontitis is an inflammatory and destructive disease of tooth‐supporting tissue and has
become the leading cause of adult tooth loss. The most central pathological features of …

Mitochondria: An Emerging Unavoidable Link in the Pathogenesis of Periodontitis Caused by Porphyromonas gingivalis

S Luo, T Xu, Q Zheng, A Jiang, J Zhao, Y Ying… - International Journal of …, 2024 - mdpi.com
Porphyromonas gingivalis (P. gingivalis) is a key pathogen of periodontitis. Increasing
evidence shows that P. gingivalis signals to mitochondria in periodontal cells, including …

Mitochondrial dysfunction in the pathogenesis and treatment of Oral inflammatory diseases

Z Dong, L Wu, H Hong - International Journal of Molecular Sciences, 2023 - mdpi.com
Oral inflammatory diseases (OIDs) include many common diseases such as periodontitis
and pulpitis. The causes of OIDs consist microorganism, trauma, occlusal factors …

Mitochondrial dysfunction is involved in the aggravation of periodontitis by diabetes

X Sun, Y Mao, P Dai, X Li, W Gu… - Journal of Clinical …, 2017 - Wiley Online Library
Aim To elucidate whether mitochondrial dysfunction contributes to aggravated periodontitis
in diabetes. Materials and Methods Sixty‐four wistar rats were randomly assigned into four …

Mitochondrial homeostasis in odontoblast: Physiology, pathogenesis and targeting strategies

X Meng, H Mao, M Wan, L Lu, Z Chen, L Zhang - Life Sciences, 2024 - Elsevier
Caries and pulpitis remain a major global disease burden and affect the quality of life of
patients. Odontoblasts are key players in the progression of caries and pulpitis, not only …

Integrated machine learning and Bioinformatic analyses constructed a network between mitochondrial dysfunction and immune microenvironment of periodontitis

H Chen, L Peng, Z Wang, Y He, X Zhang - Inflammation, 2023 - Springer
Periodontitis is a prevalent and persistent inflammatory condition that impacts the supporting
tissues of the teeth, including the gums and bone. Recent research indicates that …

Abnormal mitochondrial structure and function are retained in gingival tissues and human gingival fibroblasts from patients with chronic periodontitis

J Liu, X Wang, F Xue, M Zheng… - Journal of periodontal …, 2022 - Wiley Online Library
Abstract Background and Objective The abnormal structure and function of mitochondria in
cells is closely associated with inflammatory diseases. However, the physiology of …

Mitochondrial dysfunction and genetic heterogeneity in chronic periodontitis

P Govindaraj, NA Khan, P Gopalakrishna, RV Chandra… - Mitochondrion, 2011 - Elsevier
We performed an extensive study on mitochondrial dysfunction in chronic periodontitis (CP).
Electron microscopic analysis of gingival cells revealed abnormal mitochondria in 60% of …

Integrated analyses revealed the potential role and immune link of mitochondrial dysfunction between periodontitis and type 2 diabetes mellitus

S Pan, LX Yang, W Zhong, H Wang, Y Lan… - International …, 2024 - Elsevier
There is a reciprocal comorbid relationship between periodontitis and type 2 diabetes
mellitus (T2DM). Recent studies have suggested that mitochondrial dysfunction (MD) could …