Bone metastasis pain, from the bench to the bedside

F Aielli, M Ponzetti, N Rucci - International Journal of Molecular Sciences, 2019 - mdpi.com
Bone is the most frequent site of metastasis of the most common cancers in men and
women. Bone metastasis incidence has been steadily increasing over the years, mainly …

Cancer induced bone pain: current management and future perspectives

R Kapoor, AK Saxena, P Vasudev, D Sundriyal… - Medical Oncology, 2021 - Springer
Recent improvements in the therapeutic armamentarium of oncology by the addition of
targeted and immunotherapeutic agents have led to an increase in the life expectancy of …

Role of the bone microenvironment in the development of painful complications of skeletal metastases

SH Park, MR Eber, DB Widner, Y Shiozawa - Cancers, 2018 - mdpi.com
Cancer-induced bone pain (CIBP) is the most common and painful complication in patients
with bone metastases. It causes a significant reduction in patient quality of life. Available …

Mechanisms of cancer-induced bone pain

T Middlemiss, BJA Laird, MT Fallon - Clinical Oncology, 2011 - Elsevier
Cancer-induced bone pain (CIBP) is common and challenging to treat. Common therapies,
such as opioids, radiotherapy and bisphosphonates, are often only partially effective. CIBP …

Bone pain in cancer patients: mechanisms and current treatment

R Zajączkowska, M Kocot-Kępska, W Leppert… - International journal of …, 2019 - mdpi.com
The skeletal system is the third most common site for cancer metastases, surpassed only by
the lungs and liver. Many tumors, especially those of the breast, prostate, lungs, and …

[HTML][HTML] Neurophysiological mechanisms of cancer-induced bone pain

XQ Zheng, Y Wu, J Huang, AM Wu - Journal of Advanced Research, 2022 - Elsevier
Abstract Background Cancer-induced Bone Pain (CIBP) is an important factor affecting their
quality of life of cancer survivors. In addition, current clinical practice and scientific research …

Cancer-induced bone pain: Mechanisms and models

AN Lozano-Ondoua, AM Symons-Liguori… - Neuroscience …, 2013 - Elsevier
Cancerous cells can originate in a number of different tissues such as prostate, breast and
lung, but often go undetected and are non-painful. Many types of cancers have a propensity …

Use of animal models in understanding cancer-induced bone pain

LM Slosky, TM Largent-Milnes… - Cancer growth and …, 2015 - journals.sagepub.com
Many common cancers have a propensity to metastasize to bone. Although malignancies
often go undetected in their native tissues, bone metastases produce excruciating pain that …

Bone cancer pain

JM Jimenez‐Andrade, WG Mantyh… - Annals of the New …, 2010 - Wiley Online Library
In the United States, cancer is the second most common cause of death and it is expected
that about 562,340 Americans will have died of cancer in 2009. Bone cancer pain is …

The pathophysiology of cancer-induced bone pain: current understanding

C Urch - Palliative Medicine, 2004 - journals.sagepub.com
Cancer-induced bone pain (CIBP) is a common clinical problem. Although treatment has
been revolutionised in the past 10 years with the introduction of bisphosphonates, pain …