Cancer risk loci provide special clues for uncovering pathogenesis of cancers. The
TNFRSF19 gene located within the 13q12. 12 lung cancer risk locus encodes TNF receptor …

Purpose: Lung metastasis is an important cause of breast cancer–related deaths, in which
SDF-1/CXCR4 signaling pathway plays a critical role. Single transmembrane protein LRP6 …

MRTF-A is a transcriptional co-activator being critical for multiple processes including tissue
fibrosis and cancer metastasis. The Rho-actin signaling stimulates the nuclear translocation …

Background Follistatin-like 3 (FSTL3) binds and inactivates activin, a growth factor with cell
growth and differentiation. Previous studies reported that it is overexpressed in invasive …

Distal metastasis is the major cause of death for the vast majority of lung cancer patients.
Many extracellular matrix (ECM)-related molecules are proposed to be associated with the …

Background Fibronectin type III domain containing 3B (FNDC3B) acts as an oncogene in
various cancers, and abnormal expression of FNDC3B has been found in colorectal cancer …

Objectives: keratin 16 (KRT16) is a type I cytokeratin that overexpressed in many kinds of
cancers, but unlike other keratins, KRT16 was poorly studied, so the aim of current study …

The distribution and content of fibronectin is closely related to the occurrence and
development of tumors. Fibronectin is widely involved in cell migration, adhesion …

Background Rac3 is a small GTPase multifunctional protein that regulates cell adhesion,
migration, and differentiation. It has been considered as an oncogene in breast cancer; …

Background Cold-inducible RNA binding protein (CIRP) is a newly discovered proto-
oncogene. In this study, we investigated the role of CIRP in the progression of non-small cell …