Eukaryotic genes are transcribed by RNA polymerase II (RNAP II) through cycles of
initiation, elongation and termination. Termination remains the least understood stage of …

Transcription termination occurs when a transcribing RNA polymerase releases the DNA
template and the nascent RNA. Termination is required for preventing the inappropriate …

Transcription termination signals in bacteria occur in RNA as a strong hairpin followed by a
stretch of U residues at the 3′ terminus. To release the transcript, RNA polymerase (RNAP) …

INTRODUCTION Factor-dependent transcription termination is essential to limit pervasive
transcription, maintain genome stability, balance the expression of neighboring genes, and …

Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …

The multisubunit RNAPs (RNA polymerases) found in all cellular life forms are remarkably
conserved in fundamental structure, in mechanism and in their susceptibility to sequence …

Transcriptional pausing by multisubunit RNA polymerases (RNAPs) is a key mechanism for
regulating gene expression in both prokaryotes and eukaryotes and is a prerequisite for …

Transcription termination is a fundamental process in which RNA polymerase ceases RNA
chain extension and dissociates from the chromatin template, thereby defining the end of the …

Proper RNA polymerase II (Pol II) transcription termination is essential to generate stable
transcripts, to prevent interference at downstream loci, and to recycle Pol II back to the …

Elongation, the transcriptional phase in which RNA polymerase (RNAP) moves processively
along a DNA template, occurs via a fundamental enzymatic mechanism that is thought to be …