Evolutionary related multisubunit RNA polymerases from all three domains of life, Eukarya,
Archaea and Bacteria, have common structural and functional properties. We have recently …

BACKGROUND Genes correspond to single transcription units, starting from the promoter
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …

In bacteria, premature termination of transcription by RNA polymerase (RNAP) or inhibition
of termination in DNA segments preceding targeted genes regulates processes from amino …

While it has long been appreciated that regulation of transcription initiation is vital to sustain
dynamic gene expression, recent findings suggest that the control of transcription …

RNA polymerase II (Pol II) transcribes hundreds of thousands of transcription units–a
reaction always brought to a close by its termination. Because Pol II transcribes multiple …

Transcription termination delimits transcription units but also plays important roles in limiting
pervasive transcription. We have previously shown that transcription termination occurs …

The RNA polymerase II transcription cycle is often divided into three major stages: initiation,
elongation, and termination. Research over the last decade has blurred these divisions and …

Transcription is an intrinsically dynamic process and requires the coordinated interplay of
RNA polymerases (RNAPs) with nucleic acids and transcription factors. Classical structural …

Polymerase II (Pol II) transcriptional termination depends on two independent genetic
elements: poly (A) signals and downstream terminator sequences. The latter may either …

Gene expression in organisms involves many factors and is tightly controlled. Although
much is known about the initial phase of transcription by RNA polymerase III (Pol III), the …