The role of Rat1 in coupling mRNA 3′-end processing to transcription termination: implications for a unified allosteric–torpedo model
The torpedo model of transcription termination by RNA polymerase II proposes that a 5′–
3′ RNA exonuclease enters at the poly (A) cleavage site, degrades the nascent RNA, and …
3′ RNA exonuclease enters at the poly (A) cleavage site, degrades the nascent RNA, and …
Unraveling the mechanistic features of RNA polymerase II termination by the 5′-3′ exoribonuclease Rat1
J Park, M Kang, M Kim - Nucleic acids research, 2015 - academic.oup.com
Within a complex with Rai1, the 5′-3′ exoribonuclease Rat1 promotes termination of RNA
polymerase II (RNAPII) on protein-coding genes, but its underlying molecular mechanism is …
polymerase II (RNAPII) on protein-coding genes, but its underlying molecular mechanism is …
[PDF][PDF] The ratcheted and ratchetable structural states of RNA polymerase underlie multiple transcriptional functions
S Sekine, Y Murayama, V Svetlov, E Nudler… - Molecular cell, 2015 - cell.com
Summary DNA-dependent RNA polymerase (RNAP) accomplishes multiple tasks during
transcription by assuming different structural forms. Reportedly, the" tight" form performs …
transcription by assuming different structural forms. Reportedly, the" tight" form performs …
Transcription termination: variations on common themes
O Porrua, M Boudvillain, D Libri - Trends in Genetics, 2016 - cell.com
Transcription initiates pervasively in all organisms, which challenges the notion that the
information to be expressed is selected mainly based on mechanisms defining where and …
information to be expressed is selected mainly based on mechanisms defining where and …
Controlled interplay between trigger loop and Gre factor in the RNA polymerase active centre
The highly processive transcription by multi-subunit RNA polymerases (RNAP) can be
interrupted by misincorporation or backtracking events that may stall transcription or lead to …
interrupted by misincorporation or backtracking events that may stall transcription or lead to …
A novel tandem reporter quantifies RNA polymerase II termination in mammalian cells
A Banerjee, MC Sammarco, S Ditch, J Wang… - PLoS …, 2009 - journals.plos.org
Background Making the correct choice between transcription elongation and transcription
termination is essential to the function of RNA polymerase II, and fundamental to gene …
termination is essential to the function of RNA polymerase II, and fundamental to gene …
[PDF][PDF] Effects of transcription elongation rate and Xrn2 exonuclease activity on RNA polymerase II termination suggest widespread kinetic competition
The torpedo model of transcription termination asserts that the exonuclease Xrn2 attacks the
5′ PO 4-end exposed by nascent RNA cleavage and chases down the RNA polymerase …
5′ PO 4-end exposed by nascent RNA cleavage and chases down the RNA polymerase …
Comparative overview of RNA polymerase II and III transcription cycles, with focus on RNA polymerase III termination and reinitiation
In eukaryotes, RNA polymerase (RNAP) III transcribes hundreds of genes for tRNAs and 5S
rRNA, among others, which share similar promoters and stable transcription initiation …
rRNA, among others, which share similar promoters and stable transcription initiation …
A novel conformation of RNA polymerase sheds light on the mechanism of transcription
S Tagami, S Sekine, S Yokoyama - Transcription, 2011 - Taylor & Francis
Transcription is a complicated, multistep process requiring stringent control. Its accuracy
may be achieved in part by the conformational changes of RNA polymerase (RNAP). Here …
may be achieved in part by the conformational changes of RNA polymerase (RNAP). Here …
Co-transcriptional RNA cleavage provides a failsafe termination mechanism for yeast RNA polymerase I
P Braglia, J Kawauchi, NJ Proudfoot - Nucleic acids research, 2011 - academic.oup.com
Ribosomal RNA, transcribed by RNA polymerase (Pol) I, accounts for most cellular RNA.
Since Pol I transcribes rDNA repeats with high processivity and polymerase density …
Since Pol I transcribes rDNA repeats with high processivity and polymerase density …