Many RNA polymerases terminate transcription using allosteric/intrinsic mechanisms,
whereby protein alterations or nucleotide sequences promote their release from DNA. RNA …

Transcription is a discontinuous process, where each nucleotide incorporation cycle offers a
decision between elongation, pausing, halting, or termination. Many cis-acting regulatory …

Cessation of transcription at specific terminator DNA sequences is used by viruses, bacteria,
and eukaryotes to regulate the expression of downstream genes, but the mechanisms of …

A complex network of RNA transcripts is generated from eukaryotic genomes, many of which
are processed in unexpected ways. Here, we highlight how premature transcription …

Studies of RNA polymerase II (RNAPII) transcript elongation have revealed an extremely
complex biochemical process. Obstacles to transcription, such as nucleosomes and DNA …

Intrinsic transcription termination signal in DNA consists of a short inverted repeat followed
by a T-rich stretch. Transcription of this sequence by RNA polymerase (RNAP) results in …

The primary function of RNA polymerase (RNAP) is to produce RNA transcripts optimal for a
given environmental or developmental state of a cell. RNAP accomplishes this selection by …

Pausing of RNA polymerase II (RNAP II) by backtracking on DNA is a major regulatory
mechanism in control of eukaryotic transcription. Backtracking occurs by extrusion of the 3 …

Transcriptional elongation and termination by RNA polymerase (RNAP) are controlled by
interactions among the nascent RNA, DNA, and RNAP that comprise the ternary …

Cellular life depends on transcription of DNA by RNA polymerase to express genetic
information. RNA polymerase has evolved not just to read information from DNA and write it …