Synthesis, Structure–Activity Relationships, Radiofluorination, and Biological Evaluation of [18F]RM365, a Novel Radioligand for Imaging the Human Cannabinoid …
R Teodoro, D Gündel… - Journal of Medicinal …, 2023 - ACS Publications
The development of cannabinoid receptor type 2 (CB2R) PET radioligands has been
intensively explored due to the pronounced CB2R upregulation under various pathological …
intensively explored due to the pronounced CB2R upregulation under various pathological …
Structure-Based Design, Optimization, and Development of [18F]LU13: A Novel Radioligand for Cannabinoid Receptor Type 2 Imaging in the Brain with PET
D Gundel, W Deuther-Conrad… - Journal of Medicinal …, 2022 - ACS Publications
The cannabinoid receptor type 2 (CB2R) is an attractive target for the diagnosis and therapy
of neurodegenerative diseases and cancer. In this study, we aimed at the development of a …
of neurodegenerative diseases and cancer. In this study, we aimed at the development of a …
Radiofluorination and biological evaluation of N-aryl-oxadiazolyl-propionamides as potential radioligands for PET imaging of cannabinoid CB2 receptors
R Teodoro, RP Moldovan, C Lueg, R Günther… - Organic and medicinal …, 2013 - Springer
Background The level of expression of cannabinoid receptor type 2 (CB 2 R) in healthy and
diseased brain has not been fully elucidated. Therefore, there is a growing interest to assess …
diseased brain has not been fully elucidated. Therefore, there is a growing interest to assess …
Development of [18F]LU14 for PET Imaging of Cannabinoid Receptor Type 2 in the Brain
R Teodoro, D Gündel, W Deuther-Conrad… - International Journal of …, 2021 - mdpi.com
Cannabinoid receptors type 2 (CB2R) represent an attractive therapeutic target for
neurodegenerative diseases and cancer. Aiming at the development of a positron emission …
neurodegenerative diseases and cancer. Aiming at the development of a positron emission …
Synthesis and in vitro biological evaluation of carbon-11-labeled quinoline derivatives as new candidate PET radioligands for cannabinoid CB2 receptor imaging
M Gao, M Wang, KD Miller, GD Hutchins… - Bioorganic & medicinal …, 2010 - Elsevier
Cannabinoids have been recently proposed as a new family of potential antitumor agents,
and cannabinoid receptor 2 (CB2) is believed to be over-expressed in tumor cells. This …
and cannabinoid receptor 2 (CB2) is believed to be over-expressed in tumor cells. This …
Identification and preclinical development of a 2, 5, 6-trisubstituted fluorinated pyridine derivative as a radioligand for the positron emission tomography imaging of …
A Haider, L Gobbi, J Kretz, C Ullmer… - Journal of medicinal …, 2020 - ACS Publications
Despite the broad implications of the cannabinoid type 2 receptor (CB2) in
neuroinflammatory processes, a suitable CB2-targeted probe is currently lacking in clinical …
neuroinflammatory processes, a suitable CB2-targeted probe is currently lacking in clinical …
Ruthenium-Mediated 18F-Fluorination and Preclinical Evaluation of a New CB1 Receptor Imaging Agent [18F]FPATPP
S Lahdenpohja, NA Rajala, JS Helin… - ACS Chemical …, 2020 - ACS Publications
Cannabinoid receptor 1 (CB1R) controls various physiological and pathological conditions,
including memory, motivation, and inflammation, and is thus an interesting target for positron …
including memory, motivation, and inflammation, and is thus an interesting target for positron …
18F-JHU94620, a high affinity PET radioligand for imaging of cannabinoid subtype 2 receptors (CB2R)
RP Moldovan, W Deuther-Conrad, R Teodoro, Y Wang… - 2015 - Soc Nuclear Med
1048 Objectives CB2R represents a target with increasing importance for neuroimaging due
to its upregulation in various pathological conditions. Encouraged by preliminary results …
to its upregulation in various pathological conditions. Encouraged by preliminary results …
Development of a high-affinity PET radioligand for imaging cannabinoid subtype 2 receptor
RP Moldovan, R Teodoro, Y Gao… - Journal of Medicinal …, 2016 - ACS Publications
Cannabinoid receptors type 2 (CB2) represent a target with increasing importance for
neuroimaging due to its upregulation under various pathological conditions. Encouraged by …
neuroimaging due to its upregulation under various pathological conditions. Encouraged by …
Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging
N Evens, C Vandeputte, GG Muccioli… - Bioorganic & medicinal …, 2011 - Elsevier
The type 2 cannabinoid receptor (CB2R) is part of the endocannabinoid system and is
expressed in tissues related to the immune system. As the CB2R has a very low brain …
expressed in tissues related to the immune system. As the CB2R has a very low brain …