Background T-cell immunoglobulin mucin 3 (TIM3) is a negative immune checkpoint and
plays a crucial part in tumor-induced immune suppression. However, the mechanism of …

T‐cell immunoglobulin mucin 3 (TIM 3) contributes to immune suppression during
progression of many cancers, but the precise role of TIM 3 in head and neck squamous cell …

Background T cell immunoglobulin-3 (TIM-3) has been established as a negative regulatory
molecule and plays a critical role in immune tolerance. TIM-3 is upregulated in exhausted …

Abstract Purpose: Regulatory T (Treg) cells are important suppressive cells among tumor-
infiltrating lymphocytes (TIL). Treg cells express the well-known immune checkpoint receptor …

Background: T-cell Immunoglobulin and Mucin domain-containing molecule-3 (TIM-3) is a
new immune checkpoint molecule which plays important and complex roles in regulating …

T cells play an important role in antitumor immunity, and the T cell immunoglobulin domain
and the mucin domain protein‐1 (TIM‐1) on its surface, as a costimulatory molecule, has a …

T cell immunoglobulin mucin domain-containing protein 3 (Tim-3) negatively regulates
innate and adaptive immunity in cancer. To identify the mechanisms of Tim-3 in cancer …

Tim-3 acts as a negative regulatory molecule and plays a critical role in immune tolerance.
The purpose of this study was to investigate the expression of Tim-3 on peripheral CD4+ …

T cell immunoglobulin-and mucin-domain-containing molecule-3 (Tim-3) has been shown to
play an important role in mediating NK-cell function in human diseases. However, the …

Tim-3, a member of the novel Tim (T cell immunoglobulin and mucin domain) family, has
been reported to negatively regulate the immune responses against viral infection and had …