Gene therapy: Comprehensive overview and therapeutic applications

N Sayed, P Allawadhi, A Khurana, V Singh, U Navik… - Life sciences, 2022 - Elsevier
Gene therapy is the product of man's quest to eliminate diseases. Gene therapy has three
facets namely, gene silencing using siRNA, shRNA and miRNA, gene replacement where …

[HTML][HTML] Current progress in gene delivery technology based on chemical methods and nano-carriers

L Jin, X Zeng, M Liu, Y Deng, N He - Theranostics, 2014 - ncbi.nlm.nih.gov
Gene transfer methods are promising in the field of gene therapy. Current methods for gene
transfer include three major groups: viral, physical and chemical methods. This review …

A review of the tortuous path of nonviral gene delivery and recent progress

D Sharma, S Arora, J Singh, B Layek - International journal of biological …, 2021 - Elsevier
Gene therapy encompasses the transfer of exogenous genetic materials into the patient's
target cells to treat or prevent diseases. Nevertheless, the transfer of genetic material into …

[PDF][PDF] Vectors and delivery systems in gene therapy

R Gardlik, R Pálffy, J Hodosy, J Lukács, J Turna… - Med Sci …, 2005 - academia.edu
Gene therapy provides modern medicine with new perspectives that were unthinkable two
decades ago. Progress in molecular biology and, especially, molecular medicine is now …

[HTML][HTML] Non viral vectors in gene therapy-an overview

M Ramamoorth, A Narvekar - Journal of clinical and diagnostic …, 2015 - ncbi.nlm.nih.gov
Non-viral vectors are simple in theory but complex in practice. Apart from intra cellular and
extracellular barriers, number of other challenges also needs to be overcome in order to …

[HTML][HTML] Delivery systems for gene therapy

S Mali - Indian journal of human genetics, 2013 - ncbi.nlm.nih.gov
The structure of DNA was unraveled by Watson and Crick in 1953, and two decades later
Arber, Nathans and Smith discovered DNA restriction enzymes, which led to the rapid …

[HTML][HTML] Novel gene delivery systems

SB Manjila, JN Baby, EN Bijin… - International journal …, 2013 - ncbi.nlm.nih.gov
Gene therapy is an emerging field in medical and pharmaceutical sciences because of its
potential in treating chronic diseases like cancer, viral infections, myocardial infarctions, and …

[HTML][HTML] Appraisal for the potential of viral and nonviral vectors in gene therapy: A review

MH Butt, M Zaman, A Ahmad, R Khan, TH Mallhi… - Genes, 2022 - mdpi.com
Over the past few decades, gene therapy has gained immense importance in medical
research as a promising treatment strategy for diseases such as cancer, AIDS, Alzheimer's …

Gene therapy and DNA delivery systems

D Ibraheem, A Elaissari, H Fessi - International journal of pharmaceutics, 2014 - Elsevier
Gene therapy is a promising new technique for treating many serious incurable diseases,
such as cancer and genetic disorders. The main problem limiting the application of this …

In pursuit of new developments for gene therapy of human diseases

G Palu, R Bonaguro, A Marcello - Journal of biotechnology, 1999 - Elsevier
Gene therapy aims at transferring a therapeutic gene into human somatic cells in order to
treat a disease. Originally addressed to hereditary genetic disorders, gene therapy has …