[PDF][PDF] New insights into mechanisms of atrial fibrillation.

B Aldhoon, V Melenovský, P Peichl, J Kautzner - Physiological research, 2010 - Citeseer
Although atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice,
precise mechanisms that lead to the onset and persistence of AF have not completely been …

Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation

O Adam, K Theobald, D Lavall, M Grube… - Journal of molecular and …, 2011 - Elsevier
The aim of the study is to characterize the signal transduction leading to interstitial fibrosis in
the pathogenesis of atrial fibrillation (AF) and atrial remodeling. Samples of the left atrial …

Fibrosis and atrial fibrillation: computerized and optical mapping: a view into the human atria at submillimeter resolution

BJ Hansen, J Zhao, VV Fedorov - JACC: Clinical Electrophysiology, 2017 - jacc.org
Recent studies strongly suggest that the majority of atrial fibrillation (AF) patients with
diagnosed or subclinical cardiac diseases have established or even pre-existing fibrotic …

Current concepts in the pathogenesis of atrial fibrillation

A Kourliouros, I Savelieva, A Kiotsekoglou… - American heart …, 2009 - Elsevier
Current evidence suggests that the pathogenesis of atrial fibrillation (AF) is multifactorial.
The observation that AF, once present, alters the electrophysiologic properties of the atrial …

Mounting evidence that fibrosis generates a major mechanism for atrial fibrillation

MS Spach - Circulation Research, 2007 - Am Heart Assoc
It is widely known that atrial fibrillation (AF) is the most common sustained cardiac
arrhythmia, with the problem magnified by the clinical sequelae; eg, thromboembolic events …

Atrial remodeling and atrial fibrillation: recent advances and translational perspectives

S Nattel, M Harada - Journal of the American College of Cardiology, 2014 - jacc.org
Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. AF and its
complications are responsible for important population morbidity and mortality. Presently …

Atrial cardiomyopathy in valvular heart disease: From molecular biology to clinical perspectives

AÁ Molnár, A Sánta, DT Pásztor, B Merkely - Cells, 2023 - mdpi.com
This review discusses the evolving topic of atrial cardiomyopathy concerning valvular heart
disease. The pathogenesis of atrial cardiomyopathy involves multiple factors, such as …

Structural remodeling in atrial fibrillation

D Corradi, S Callegari, R Maestri, S Benussi… - Nature clinical practice …, 2008 - nature.com
Atrial fibrillation occurs and maintains itself in the context of a morphologically and
functionally altered atrial substrate that can be induced by stressors such as underlying …

Slow conduction in the border zones of patchy fibrosis stabilizes the drivers for atrial fibrillation: insights from multi-scale human atrial modeling

R Morgan, MA Colman, H Chubb, G Seemann… - Frontiers in …, 2016 - frontiersin.org
Introduction: The genesis of atrial fibrillation (AF) and success of AF ablation therapy have
been strongly linked with atrial fibrosis. Increasing evidence suggests that patient-specific …

Left ventricular fibrosis in atrial fibrillation

E Shantsila, A Shantsila, AD Blann, GYH Lip - The American journal of …, 2013 - Elsevier
Excessive atrial fibrosis is involved in the pathogenesis of atrial fibrillation (AF), but little is
known of left ventricular (LV) fibrotic status in patients with AF. In the present study, we …