Changes in DNA methylation have been causally linked with cancer and provide promising
biomarkers for detection in biological fluids such as blood, urine, and saliva. The field has …

DNA methylation is a common mechanism of inactivation of tumour-suppressor and other
cancer genes in neoplastic cells. The advantages of gene methylation as a target for the …

Background Better prognostic outcome is closely correlated with early detection of bladder
cancer. Current non-invasive urianalysis relies on simultaneously testing multiple …

BACKGROUND Current methods for the detection and surveillance of bladder cancer (BCa)
are often invasive and/or possess suboptimal sensitivity and specificity, especially in early …

Recently, there has been a great effort to develop tests based on non-invasive urinary
biomarkers (NMIBCs). These tests are based on the fact that NMIBCs are heterogeneous at …

Purpose: This study aims to provide a better set of DNA methylation markers in urine
sediments for sensitive and specific detection of bladder cancer. Experimental Design: Fifty …

Background The development of accurate urinary biomarkers for non-invasive and cost-
effective detection of primary and recurrent bladder tumours is recognized as one of the …

DNA methylation analysis of full void urine and urine pellet seems promising for bladder
cancer (BC) detection and surveillance. Urinary cell-free DNA from urine supernatant is now …

Urinary DNA is increasingly gaining importance in diagnosis of urological malignancies.
Especially cell-free DNA originating from apoptotic and necrotic cells of the early tumor …

Background Early detection and risk assessment are crucial for treating urothelial cancer
(UC), which is characterized by a high recurrence rate, and necessitates frequent and …